USE OF CHOLUDEXAN TO TREAT ANTITUBERCULOSIS DRUG-INDUCED LIVER INJURY 1

Abstract

The efficacy and safety of choludexan used to treat antituberculosis drug-induced liver injury were studied in 80 patients with respiratory organ tuberculosis. The indicators of liver functional test became normal in 20 patients with no history of hepatitis and in the group of patients with tuberculosis concurrent with hepatitis B and C virus infection by days 10 and 15 of choludexan administration, respectively; liver dysfunctions recovered in the group of patients with tuberculosis concurrent with chronic alcoholism at the time exceeding the reference one. In terms of the findings, choludexan may be recommended for the treatment of antituberculosis drug-induced liver injury. Longer choludexan cycles up to 30 days or more should be used in patients with tuberculosis concurrent with chronic alcoholism when the indicators of liver functional tests recover slowly.