GENETIC STRUCTURE AND DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS POPULATION IN THE CIVIL SECTOR OF THE KYRGYZ REPUBLIC
Abstract
The genetic structure of drug-resistant and drug-susceptible Mycobacterium tuberculosis (MBT) circulating in the civil sector of the Kyrgyz Republic was analyzed. One hundred and three MBT DNA samples isolated from the expectoration of patients with new-onset pulmonary tuberculosis were examined. MBT was genotyped by the spoligotyping method; its resistance to rifampicin and isoniazid was determined using a TB-Biochip kit. The TB population circulating in the Kyrgyz Republic was characterized by a predominance of Beijing family strains (59.2%). The other strains represented the following families: Т (n = 14), LAM (n = 9), Ural-1 (n = 3), Ural-2 (n = 6), and others (n = 9). Multidrug-resistant strains were statistically significantly more frequently found in the genetic Beijing family than in other genotypes (p = 0.03). Thus, the circulation of drug-resistant Beijing MBT strains is a major factor that complicates the current tuberculosis situation in the Kyrgyz Republic.
About the Authors
Zh. T. Isakova
Институт молекулярной биологии и медицины
Kyrgyzstan
г. Бишкек
Kyrgyzstan
г. Бишкек
I. V. Mokrousov
НИИ эпидемиологии и микробиологии им. Пастера
Russian Federation
г. Санкт-Петербург
Russian Federation
г. Санкт-Петербург
N. Rastogi
Институт Пастера Гваделупы
France
France
A. A. Aldashev
Институт молекулярной биологии и медицины
Kyrgyzstan
г. Бишкек
Kyrgyzstan
г. Бишкек
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Review
For citations:
Isakova Zh.T., Mokrousov I.V., Rastogi N., Aldashev A.A. GENETIC STRUCTURE AND DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS POPULATION IN THE CIVIL SECTOR OF THE KYRGYZ REPUBLIC. Tuberculosis and Lung Diseases. 2014;(3):54-58. (In Russ.)
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