CHANGES IN SENSITIVITY TO SKIN TEST WITH RECOMBINANT TUBERCULOUS ALLERGEN IN CHILDREN WITH LATENT TUBERCULOSIS INFECTION
Abstract
The sensitivity to tuberculin and recombinant tuberculous allergen was assessed in 433 children with latent tuberculous infection from various epidemic conditions [exposure to a TB case (n = 202), from healthy surrounding (n = 231); changes in the results of diaskintest were assessed in 209 children (when notified and in 12 months). It was found out that expressiveness and changes in the sensitivity to tuberculous recombinant allergen depends on the epidemic conditions to which the child is exposed. The most often the conversion of the diaskintest was observed after preventive treatment in those with doubtful (95.5%) and hyperergic (82.6%) sensitivity. Conversion of the test from negative to positive was most often observed in children from healthy surroundings.
About the Authors
E. P. Shilova
Novosibirsk State Medical University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
L. V. Poddubnaya
Novosibirsk State Medical University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
I. M. Stepchenko
Children Polyclinic
Russian Federation
Ob, Novosibisrk Region
Russian Federation
Ob, Novosibisrk Region
V. G. Kononenko
Novosibirsk State Medical University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
References
1. Аksenova V.А., Baryshnikova L.А., Sevost'yanova T.А. et al. Tuberculosis in children in Russia and the tasks of tuberculosis service and general pediatric service on prevention and early detection of the disease. Tub., 2014, no. 3, pp. 40-46. (In Russ.)
2. Aksenova V.A., Levi D.T. et al. Detection of tuberculosis and tactics of dispensary follow up for those from risk groups of falling ill with tuberculosis with the use of Diaskintest® (tuberculous recombinant allergen). Tub., 2010, no. 2, pp. 13-19. (In Russ.)
3. Poddubnaya L.V., Shilova E.P., Stepchenko I.M., Kononenko V.G. Diagnostics of activeness of tuberculous infection in children. Tub., 2013, no. 9, pp. 16-19. (In Russ.)
4. Poddubnaya L.V., Shilova E.P., Egoshina I.Yu. et al. Diagnosis of tuberculous infection and its being active in children. Tub., 2013, no. 6. pp. 70-71. (In Russ.)
5. Slogotskaya L.V. Skin immunological tests in tuberculosis - history and present time. Tub., 2013, no. 5, pp. 39-43. (In Russ.)
6. Slogotskaya L.V., Kochetkov O.Yu. et al. Changes in skin test (diaskintest) in children when assessing the activity of tuberculosis infection. Tub., 2011, no. 2, pp. 59-63. (In Russ.)
Review
For citations:
Shilova E.P., Poddubnaya L.V., Stepchenko I.M., Kononenko V.G. CHANGES IN SENSITIVITY TO SKIN TEST WITH RECOMBINANT TUBERCULOUS ALLERGEN IN CHILDREN WITH LATENT TUBERCULOSIS INFECTION. Tuberculosis and Lung Diseases. 2015;(9):19-23. (In Russ.)
Views:
614
Email this article 