DRUG-INDUCED LIVER LESIONS AND THEIR MANAGEMENT IN THE MANIFESTATIONS OF TUBERCULOSIS
Abstract
The e`ciency of medication of remaxol for the management of liver lesions induced by anti-tuberculosis drugs was studied in 177 respiratory tuberculosis patients, divided into 3 groups: 1st group included 68 patients with no history of viral hepatitis and HIV infection; 2nd group included 52 patients with tuberculosis and HIV co-infection (patients from the 1st and 2nd groups received 10 day treatment with remaxol in case of drug-induced liver lesions) and 3rd control group included 57 patients (who received adamethioninum – heptor for management of the drug-induced liver lesions). 4.4% of patients from the 1st group, 7.6% from the 2nd group and 5.3% of control group manifested the improvement of the functional liver tests by the 18-20th days of the follow-up. In case of expressed concurrent conditions (viral hepatitis, diabetes etc.) and low improvement of aminotransferase level the duration of treatment of remaxol was extended up to 15 injections. Given the obtained results remaxol can be recommended for treatment of drug-induced liver lesions caused by the intake of anti-tuberculosis drugs. Tuberculosis patients with concurrent chronic alcohol addiction, HIV-infection, decompensated diabetes with low improvement of functional liver tests can be recommended to have longer treatment courses with remaxol: 15 infusions and more.
About the Authors
A. V. Mordyk
Omsk State Medical University
Russian Federation
Omsk
Russian Federation
Omsk
O. G. Ivanova
Omsk State Medical University
Russian Federation
Omsk
Russian Federation
Omsk
L. A. Nagibina
Clinical TB Dispensary no. 4
Russian Federation
Omsk
Russian Federation
Omsk
S. V. Sitnikova
Clinical TB Dispensary no. 4
Russian Federation
Omsk
Russian Federation
Omsk
O. A. Marekhina
Clinical TB Dispensary no. 4
Russian Federation
Omsk
Russian Federation
Omsk
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Review
For citations:
Mordyk A.V., Ivanova O.G., Nagibina L.A., Sitnikova S.V., Marekhina O.A. DRUG-INDUCED LIVER LESIONS AND THEIR MANAGEMENT IN THE MANIFESTATIONS OF TUBERCULOSIS. Tuberculosis and Lung Diseases. 2015;(9):47-53. (In Russ.)
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