EXPERIENCE OF USING TUBERCULOUS RECOMBINANT ALLERGEN FOR DIAGNOSTICS OF TUBERCULOSIS IN HIV PATIENTS

Abstract

The high level of HIV infection is one of the factors providing negative impact on tuberculosis incidence and prevalence in Sverdlovsk region. The number of those su|ering from the late stage of HIV-infection is steadily increasing and they develop active tuberculosis fast. The purpose of the study is to evaluate the results of using tuberculous recombinant allergen in the procedure of tuberculosis diagnostics in HIV patients. 4144 HIV patients were enrolled into the study, some of them had tests with tuberculous recombinant allergen (diaskintest) and the others had tuberculin tests. Tuberculous recombinant allergen proved to be more sensitive compared to tuberculin in the planned examination of HIV patients with the purpose of tuberculosis detection. In case of positive or hyperergic reaction to tuberculous recombinant allergen active tuberculosis was detected 4.8 fold often in HIV patients compared to the same reactions to tuberculin. The procedure of preventive examination for tuberculosis in HIV patients should include tuberculous recombinant allergen.