SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA
https://doi.org/10.21292/2075-1230-2016-94-12-26-32
Abstract
Goal of the study: evaluation of the impact of single nucleotide polymorphism (SNP) of rs4129267 gene of interleukin 6 receptor, (IL6R), rs1051730 gene of nicotine receptor 3 (CHRNA3) in the formation of predisposition to asthma among citizens of Krasnoyarsk.
Materials and methods. Group of asthma patients included 100 persons while control group included 290 persons. The control group included population sample of relatively healthy people without broncho-pulmonary disorders, residing in Novosibirsk and examined within framework of the international projects of MONICA (Multinational MONItoring of trends and determinants in СArdiovascular disease) and HAPIEE (Health, Alcohol and Psychosocial factors In Eastern Europe).
Results of the study. The association was detected between non-allergic asthma and SNP rs4129267 of gene IL6R. The association of asthma with rs1051730 of gene CHRNA3 has not been confirmed.
About the Authors
I. I. Cherkashina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor of General Medicine Department no. 1,
1, Partizana Zheleznyaka St., Krasnoyarsk, 660022
A. V. Razvodovskaya
Krasnoyarsk Inter-Regional Clinical Hospital no. 4
Russian Federation
Russian Federation
General Practitioner,
71, Kutuzov St.,Krasnoyarsk, 660094
S. Yu. Nikulina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Vice Principal on Training Activities,
1, Partizana Zheleznyaka St., Krasnoyarsk, 660022
V. N. Maksimov
Research Institute of Therapy and Preventive Medicine
Russian Federation
Russian Federation
Doctor of Medical Sciences, Senior Researcher,
175/1, Borisa Bogatkova St., Novosibirsk, 630089
A. B. Averianov
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Resident of General Medicine Department no. 1,
1, Partizana Zheleznyaka St., Krasnoyarsk, 660022
References
1. Globalnaya strategiya lecheniya i profilaktiki bronkhialnoy astmy (GINA) [Global strategy for treatment and prevention of asthma]. Revision as of 2011, ed. by A.G. Chuchalin, Moscow, Atmoshera Publ., 2011, pp. 17.
2. Demko I.V., Danilova L.I., Petrova M.M. Epidemiologiya khronicheskikh zabolevaniy organov dykhaniya u zhiteley selskoy mestnosti yuga Krasnoyarskogo kraya. [Epidemiology of chronic respiratory diseases in rural citizens in the southern regions of Krasnoyarsky Kray]. Krasnoyarsk, Ofisnaya Planeta Publ., 2012, 176 p.
3. Ketlinskiy S.А., Simbirtsev А.S. Tsitokiny. [Cytokines]. St. Petersburg, Foliant Publ., 2008, 552 p.
4. Smirnova А.Yu., Gnoevykh V.V., Portnova Yu.А. Genetic aspects of multi-factorial bronchial obstructive diseases. Ulyanovsk. Med.-Biol. Journ., 2014, no. 1, pp. 8-18. (In Russ.)
5. Smith C., Calco C., Cantor C. Puls-elektroforez i metody raboty s bolshimi molekulami DNK. (Russ. Ed.: Smith C., Calco C., Cantor C.PULSED-FIELD GEL ELECTROPHORESIS OF VERY LARGE DNA MOLECULES.) Moscow, Mir Publ., 1990, pp. 58-94.
6. Smolnikova M.V., Smirnova S.V., Tyutina O.S. Polymorphism of cytokine genes in allergic asthma. Sib. Med. Obozreniye, 2013, no. 2, pp. 3-9. (In Russ.)
7. Fedoseev G.B., Trofimov V.I., Shaylieva L.O. et al. Multifaced asthma - phenotypes and clinical pathogenic variants. Ros. Allergogol. Journ., 2012, no. 1, pp. 50-57. (In Russ.)
8. Cherkashina I.I., Nikulina S.Yu., Shestovitskiy V.А. et al. Specific polymorphism of CCR2 chemokine receptor gene in those suffering from asthma and chronic obstructive pulmonary disease. Sib. Med. Obozreniye, 2013, no. 3, pp. 17-21. (In Russ.)
9. Bartolomei-Diaz J.A., Amill-Rosario A., Claudio L. et al. Asthma mortality in Puerto Rico: 1980-2007. J. Asthma, 2011, vol. 48, no. 2, pp. 202-209.
10. Bottema R.W., Kerkhof M., Reijmerink N.E. et al. Gene-gene interaction in regulatory T-cell function in atopyandasthma development in childhood. J. Allergy Clin. Immunol., 2010, vol. 126, no. 2, pp. 338-346.
11. Bunyavanich S., Schadt E.E. Systems biology of asthma and allergic diseases: a multiscale approach. J. Allergy Clin. Immunol., 2015, vol. 135, no. 1, pp. 31-42.
12. Duru S., Kurt E.B. Asthma, environment and epigenetic. Tuberk. Toraks., 2014, vol. 62, no. 2, pp. 165-169.
13. Ferreira M.A., Matheson M.C., Duffy D.L. et al. Identification of IL6Rand chromosome 11q13.5 as risk loci for asthma. Lancet, 2011, vol. 378, no. 9795, pp. 1006-1014.
14. Hawkins G.A., Robinson M.B., Hastie A.T. et al. The IL6R variation Asp(358) Ala is a potential modifier of lung function in subjects with asthma. J. Allergy Clin. Immunol., 2012, vol. 130, no. 2, pp. 510-515.
15. Holloway J.W., Arshad S.H., Holgate S.T. Using genetics to predict the natural history of asthma? J. Allergy Clin. Immunol., 2010, vol. 126, no. 2, pp. 200-209.
16. Kaur-Knudsen D., Nordestgaard B.G., Bojesen S.E. CHRNA3 genotype, nicotine dependence, lung function and disease in the general population. Eur. Respir. J., 2012, vol. 40, no. 6, pp. 1538-1544.
17. Li X., Hawkins G.A., Ampleford E.J. et al. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J. Allergy Clin. Immunol., 2013, vol. 132, no. 2, pp. 313-320.e15.
18. Mathias R.A. Introduction to genetics and genomics in asthma: genetics of asthma. Adv. Exp. Med. Biol., 2014, vol. 795, pp. 125-155.
19. Padrón-Morales J., García-Solaesa V., Isidoro-García M. et al. Implications of cytokine genes in allergic asthma. Allergol. Immunopathol. (Madr)., 2014, vol. 42, no. 6, pp. 603-608.
20. Revez J.A., Bain L., Powell J.E. et al. A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk. Genes Immun., 2013, vol. 14, no. 7, pp. 441-446.
21. Taga T., Hibi M., Hirata Y. et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell, 1989, vol. 58, no. 3, pp. 573-581.
22. Wilk J.B., Shrine N.R., Loehr L.R. et al. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am. J. Respir. Crit. Care Med., 2012, vol. 186, no. 7, pp. 622-632.
Review
For citations:
Cherkashina I.I., Razvodovskaya A.V., Nikulina S.Yu., Maksimov V.N., Averianov A.B. SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA. Tuberculosis and Lung Diseases. 2016;94(12):26-32. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-12-26-32
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