FREQUENCY OF DETECTION AND SPECIFIC MORPHOLOGY OF NON-TUBERCULOUS MYCOBACTERIOSIS IN THOSE AT THE ADVANCED STAGE OF HIV (AS PER DATA FROM ORENBURG REGION)
https://doi.org/10.21292/2075-1230-2016-94-12-57-61
Abstract
Goal: to define frequency of detection of non-tuberculous mycobacterioses in Orenburg Region and to study the morphology of the autopsy samples of the patients suffering from HIV infection and non-tuberculous mycobacteriosis.
Materials and methods. 7488 mycobacterial cultures were analyzed in order to differentiate non-tuberculous mycobacteria and to identify their species by molecular genetic methods. Post mortem diagnostics was performed with morphological description of generalized forms of mycobacterioses caused by M. avium.
Results. The analysis showed that species of Mycobacterium tuberculosis complex significantly prevailed (98.9%) in Orenburg Region. The following non-tuberculous mycobacteria were found in HIV negative patients: M. avium complex, M. xenopi, M. gordonae. M. avium was the most common in HIV positive patients (75%). Non-tuberculous mycobacteriosis possesses a specific diagnostic feature i.e. detection of non-caseous granulomas, consisting of histiocytes and "foamy" macrophages, containing large number of acid-fast mycobacteria in cytoplasm. Diffusive fibrosis of macrophage-histiocyte granulomas and sclerosis of tissue in perifocal area of inflammation are the typical features of it.
About the Authors
A. M. Mikhailovskiy
Orenburg Regional Clinical Anti-tuberculosis Dispensary
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of Autopsy Department,
6, Nezhinskoye Rd, Orenburg, 460041
S. A. Churkin
Orenburg Regional Clinical Anti-tuberculosis Dispensary
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head Doctor,
6, Nezhinskoye Rd, Orenburg, 460041
N. A. Pashkova
Orenburg Regional Clinical Anti-tuberculosis Dispensary
Russian Federation
Russian Federation
Laboratory Head,
6, Nezhinskoye Rd, Orenburg, 460041
L. N. Lepekha
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Biological Sciences, Professor, Head of Department for Pathoanatomy, Cellular Biology and Biochemistry,
2, Yauzskaya Alleya, Moscow, 107564
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Review
For citations:
Mikhailovskiy A.M., Churkin S.A., Pashkova N.A., Lepekha L.N. FREQUENCY OF DETECTION AND SPECIFIC MORPHOLOGY OF NON-TUBERCULOUS MYCOBACTERIOSIS IN THOSE AT THE ADVANCED STAGE OF HIV (AS PER DATA FROM ORENBURG REGION). Tuberculosis and Lung Diseases. 2016;94(12):57-61. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-12-57-61
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