The lethal case of generalized mycobacteriosis in the patient at the terminal stage of HIV-infection
https://doi.org/10.21292/2075-1230-2016-94-4-57-62
Abstract
The article presents the brief data from literature and the own observation of the lethal case due to mycobacteriosis caused by M. avium in 33 year old patient at the terminal stage of HIV. The disease developed by lesions in the intestinal tract and various groups of lymph nodes which histologically manifested by formation of fields consisting of spindle-shaped histiocytes and macrophages with foam cytoplasm containing the significant number of acid-fast bacilli. Expressed necrotic changes were minimum and classic epithelioid cell granulomas were absent. Culture of M. avium was isolated and verified by molecular-genetic techniques intravitally out of fecal matters and post mortem out of intestinal and lymph node tissue.
About the Authors
R. B. Berdnikov
Ural State Medical University;
Ural Phthisiopulmonology Research Institute; Sverdlovsk Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Candidate of Medical Sciences, Senior Researcher of Laboratory for Diagnostic and Experimental Testing Techniques, Associate Professor of Pathologic Anatomy Department of Ural State Medical University, Russian Ministry of Health,
50, XXII Parts"ezda St., Yekaterinburg, Sverdlovsk Region, 620039
L. M. Grinberg
Ural State Medical University;
Ural Phthisiopulmonology Research Institute; Sverdlovsk Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Ural State Medical University, Russian Ministry of Health, Doctor of Medical Sciences, Professor, Head of Pathologic Anatomy Department, Chief Researcher of Ural Phthisiopulmonology Research Institute, Russian Ministry of Health, Head of Sverdlovsk Regional TB Dispensary,
3, Repina St., Yekaterinburg, Svedlovsk Region, 620028
A. Yu. Evseev
Sverdlovsk Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Sverdlovsk Regional TB Dispensary, TB Doctor,
9, Chapaeva St., Yekaterinburg, Sverdlovsk Region, 620142
E. Yu. Kamaev
Ural Phthisiopulmonology Research Institute
Russian Federation
Russian Federation
Candidate of Medical Sciences, Researcher of Laboratory for Diagnostic and Experimental Testing Techniques,
50, XXII Parts"ezda St., Yekaterinburg, Sverdlovsk Region, 620039
M. A. Kravchenko
Ural Phthisiopulmonology Research Institute
Russian Federation
Russian Federation
Candidate of Biological Sciences, Head of Laboratory for Diagnostic and Experimental Testing Techniques,
50, XXII Parts"ezda St., Yekaterinburg, Sverdlovsk Region, 620039
References
1. Berdnikov R.B., Grinberg L.M., Sorokina N.D. et al. HIV-infection and tuberculosis as per autopsy data. Ural. Med. J., 2011, no. 1, pp. 67-72. (In Russ.)
2. Zholobov V.E. Death causes in HIV/AIDS patients as per reporting statistic data. Med.-Biol. i Sotsial.-Psichol. Problemy Bezopasnosti v Chrezvychainykh Situatsiyakh, 2010, no. 4-1, pp. 53-56. (In Russ.)
3. Zimina V.N., Kravchenko А.V., Zyuzya Yu.R. et al. Specific course of tuberculosis with other concurrent opportunistic disease in HIV-patients. VICH-Infektsiya i Immunosuprssiya, 2011, vol. 3, no. 3, pp. 45-51. (In Russ.)
4. Kamaeva N.G., Grinberg L.M., Chugaev Yu.P. et al. Skhema Differentsial’naya diagnostika ostitov s morfologicheskimi priznakami produktivno-nekroticheskogo tuberkuleza u detey. [The diagram of differential diagnostics of ostitis with morphological signs of productive necrotic tuberculosis in children]. RF Patent no. 83318 as of 16.10.2012.
5. Otten T.F., Vasiliev А.V. Mikobaketerioz. [Mycobacteriosis.] St. Petersburg, 200, 219 p.
6. Parkhomenko Yu.G., Erokhin V.V., Zyuzya Yu.R. et al. Pathomorphological changes in the lungs in case of tuberculosis in those died of HIV-infection at the stage of AIDS. Arkhiv Patologii, 2007, no. 3, pp. 26-28. (In Russ.)
7. Fomenkova N.V., Leonova O.N., Vinogradova T.N. et al. Atypical mycobacteriosis as an opportunistic disease in HIV patients. Med.-Biol. i Sotsial.-Psichol. Problemy Bezopasnosti v Chrezvychainykh Situatsiyakh, 2011, no. 3, pp. 52-57. (In Russ.)
8. Tsinzerling V.А., Svistunov V.V., Karev V.E. et al. Morphological diagnostics of in the current situation. Arkhiv Patologii, 2015, no. 3, pp. 3-10. (In Russ.)
9. Chen K.T. Mycobacterial spindle cell pseudotumor of lymph nodes. Am. J. Surg. Pathol., 1992, vol. 16, no. 3, pp. 276-281.
10. Farhi D.C., Mason U.G., Horsburgh C.R.Jr. Pathologic findings in disseminated Mycobacterium avium-intracellulare infection. A report of 11 cases. Am.J.Clin. Pathol., 1986, vol. 85, no. 1, pp. 67-72.
11. Kim Y.N., Kim K.M., Choi H.N. Clinical usefulness of PCR for differential diagnosis of tuberculosis and nontuberculous Mycobacterial infection in paraffin-embedded lung tissues. J. Mol. Diagn., 2015, vol. 17, no. 5, pp. 597-604.
12. Mayskaya M.U., Otten T.F., Ariel B.M. et al. Morphological manifestations of the atypical mycobacteriosis caused by nontuberculous mycobacteria in the HIV infected patients. Ann. Clin. Lab. Sci., 2014, vol. 44, no. 2, pp. 131-133.
13. Morrison A., Gyure K.A., Stone J. et al. Mycobacterial spindle cell pseudotumor of the brain: a case report and review of the literature. Am. J. Surg Pathol., 1999, vol. 23, no. 10, pp. 1294-1299.
Review
For citations:
Berdnikov R.B., Grinberg L.M., Evseev A.Yu., Kamaev E.Yu., Kravchenko M.A. The lethal case of generalized mycobacteriosis in the patient at the terminal stage of HIV-infection. Tuberculosis and Lung Diseases. 2016;94(4):57-62. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-4-57-62
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