GENETIC CHARACTERISTICS AND DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN PATIENTS WITH TUBERCULOSIS AND HIV INFECTION IN THE IRKUTSK REGION
https://doi.org/10.21292/2075-1230-2014-0-6-42-45
Abstract
The paper gives the results of examination in 322 patients excreting bacteria (148 patients with pulmonary tuberculosis and HIV infection and 174 patients with pulmonary tuberculosis) by culture methods and the 12 locus MIRU-VNTR genotyping (WHO, 2009), by using the open database MIRU-VNTRplus (Weniger T. et al., 2010). Drug resistance in Mycobacterium tuberculosis is encountered in inpatients with tuberculosis and in those with tuberculosis concurrent with HIV infection equally frequently (76.4 and 85.1%, respectively). In patients with tuberculosis and HIV infection, resistance to reserve drugs is seen less frequently than in those with tuberculosis. The Beijing genotype was identified in 76.3% of patients with tuberculosis and HIV infection and in 65.5% of tuberculosis patients without comorbidity. The Beijing MIT17 genotype is associated with multidrug resistance in 48.8% of cases.
About the Authors
E. Yu. Zorkaltseva
ГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования» МЗ РФ
Russian Federation
Russian Federation
O. B. Ogarkov
ФГБУ «Научный Центр проблем здоровья семьи и репродукции человека» СО РАМН
Russian Federation
г. Иркутск
Russian Federation
г. Иркутск
S. N. Zhdanova
ФГБУ «Научный Центр проблем здоровья семьи и репродукции человека» СО РАМН
Russian Federation
г. Иркутск
Russian Federation
г. Иркутск
S. I. Alekseeva
ГБУЗ «Иркутский областной противотуберкулезный диспансер»
Russian Federation
Russian Federation
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Review
For citations:
Zorkaltseva E.Yu., Ogarkov O.B., Zhdanova S.N., Alekseeva S.I. GENETIC CHARACTERISTICS AND DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN PATIENTS WITH TUBERCULOSIS AND HIV INFECTION IN THE IRKUTSK REGION. Tuberculosis and Lung Diseases. 2014;(6):42-45. (In Russ.) https://doi.org/10.21292/2075-1230-2014-0-6-42-45
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