CONTENT OF PENTRAXIN-3 AND C-REACTIVE PROTEIN IN BLOOD SERUM OF CHILDREN AND ADOLESCENTS SUFFERING FROM RESPIRATORY TUBERCULOSIS WITH DESTRUCTION AND MINOR FORMS OF THE DISEASE
https://doi.org/10.21292/2075-1230-2016-94-9-44-48
Abstract
The study investigated the dynamic changes in the content of pentraxin-3 and C-Reactive Protein in blood serum of children and adolescents suffering from respiratory tuberculosis with destruction and minor tuberculous changes in chest lymph nodes and lungs (minor forms). Level of PTX3 in tuberculosis patients with destructive lesions confidently reduced by the 6th month of treatment (end of the intensive phase of treatment): from 3 285.2 ± 387.1 down to 1 280.0 ± 65.4 pg/ml In the group ofthose with minor forms oftuberculosis the content of PTX3 confidently increased after 6 months of treatment (completion of the main course of chemotherapy): from 2 990.0 ± 330.3 down 5 329.7 ± 421.3 pg/ml. Such changes of PTX3 in this group were observed for the first time and it had not been described before. It is possible that the increase of PTX3 level after completion of chemotherapy course is temporary and it is related to activation of the lung tissue healing. Content of C-Reactive Protein before treatment start was typically higher in those with destructive lesions and it confidently reduced in 6 months of chemotherapy in the patients from this group (from 15.7 ± 2.9 down to 5.95 ± 1.2 mg/l) and remained unchanged in the patients with minor forms of tuberculosis (4.5 ± 1.1; 2.9 ± 0.1 mg/l).
About the Authors
M. M. Averbakh (J.)
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical sciences, Professor, senior Researcher,
2, Yauzskaya alleya, Moscow, 107564
M. F. Gubkina
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical sciences, senior Researcher,
2, Yauzskaya alleya, Moscow, 107564
L. V. Panova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical sciences, senior Researcher,
2, Yauzskaya alleya, Moscow, 107564
References
1. Kaminskaya G.O., Abdullaev R.Yu., Komissarova O.G. Kolichestvennoe opredelenie S- reaktivnogo belka u bolnykh tuberkulezom legkikh pri dinamicheskom obsledovanii do i v protsesse lecheniya. Posobie dlya vrachey. [Quantitative testing of C-Reactive Protein in pulmonary tuberculosis patients during dynamic examination before and during treatment. Doctors’ Manual]. Moscow, 2009.
2. Alles V.V., Bottazzi B., Peri G. et al. Inducible expression of PTX3, a new member of the pentraxin family, in humanmononuclear phagocytes. Blood, 1994, vol. 84, pp. 348-349.
3. Azzurri A., So O.Y., Amedei A. et al. IFN-c-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in mycobacterium tuberculosis infection. Microbes and Infection, 2005, vol. 7, pp. 1-8.
4. Doni A., Michela M., Bottazzi B. et al. Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFNgamma. J. Leukocyte Biology, 2006, vol. 79, pp. 797-802.
5. Kirkpatrick L.L, Matzuk M.M., Dodds D.C. et al. Biochemical interactions ofthe neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. J. Biol. Chem., 2000, vol. 275, pp. 17786-17792.
6. Mantovani A., Garlanda C., Doni A. et al. Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3. J. Clin. Immunol., 2008, vol. 28, pp. 1-13. DOI 10.1007/s10875-007-9126-7.
7. Mantovani A., Valentino S., Gentile C. et al. The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules. Ann. N.Y. Acad. Sci., 2013, vol. 1285, – Р.1-14 doi: 10.1111/nyas.12043.
8. Moalli F., Jaillon S., Inforzato A. et al. Pathogen Recognition by the Long Pentraxin PTX3. J. Biomed. Biotechnol., 2011, Article ID 830421, 15 p. doi:10.1155/2011/830421.
9. Olesen R., Wejse C., Velez D.R. et al. DC-SIGN (CD209). Pentraxin 3 and Vitamin D Receptor gene variants associate with pulmonary tuberculosis risk in West-Africans. Genes and Immunity, 2007, vol. 8, pp. 456-467.
Review
For citations:
Averbakh (J.) M.M., Gubkina M.F., Panova L.V. CONTENT OF PENTRAXIN-3 AND C-REACTIVE PROTEIN IN BLOOD SERUM OF CHILDREN AND ADOLESCENTS SUFFERING FROM RESPIRATORY TUBERCULOSIS WITH DESTRUCTION AND MINOR FORMS OF THE DISEASE. Tuberculosis and Lung Diseases. 2016;94(9):44-48. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-9-44-48
Views:
862
Email this article 