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NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS

https://doi.org/10.21292/2075-1230-2017-95-2-45-50

Abstract

Role of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: in infiltrate pulmonary tuberculosis patients it was within the limits of reference ranges, and in fibrous cavernous pulmonary tuberculosis patients it was significantly lower. Results of statistical analysis point out at the significant homogeneity (monofunctionality) of the set of rates, defining the level of NO metabolites in blood serum in infiltrate pulmonary tuberculosis, namely: impact of adenosine deaminase, levels of α1-protease inhibitor, ceruleoplasmin and age. On the contrary in case of fibrous cavernous pulmonary tuberculosis the diverse (multi-functional) complexes were detected including clinical blood rates providing influence on the reduction of NO level in blood. Nitric oxide in the patients with both clinical forms of tuberculosis correlated with classical markers of system inflammatory response, thus nitric oxide can be regarded as an integral component of inflammatory response with potential evaluation of prognosis of specific lesions during follow-up of changes.

About the Authors

M. E. Dyakova
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Candidate of Biological Sciences, Senior Researcher,

32, Polytechnicheskaya St., St. Petersburg, 194064



N. P. Alekseeva
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Candidate of Mathematical Sciences, Researcher,

32, Polytechnicheskaya St., St. Petersburg, 194064



D. S. Esmedlyaeva
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Candidate of Biological Sciences, Senior Researcher,

32, Polytechnicheskaya St., St. Petersburg, 194064



T. L. Perova
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Researcher,

32, Polytechnicheskaya St., St. Petersburg, 194064



N. N. Petrischev
Pavlov First Saint Petersburg State Medical University
Russian Federation

Doctor of Medical Sciences, Professor, Head of Laser Medicine Center,

6-8, Lva Tolstogo St., St. Petersburg, 197022



P. K. Yablonskiy
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Doctor of Medical Sciences, Professor, Director,

2-4, Ligovsky Ave., St. Petersburg, 191036



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For citations:


Dyakova M.E., Alekseeva N.P., Esmedlyaeva D.S., Perova T.L., Petrischev N.N., Yablonskiy P.K. NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS. Tuberculosis and Lung Diseases. 2017;95(2):45-50. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-2-45-50

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)