IMPACT OF HIV INFECTION AND GENDER ON THE MORTALITY IN THE PATIENTS OF TUBERCULOSIS IN-PATIENT UNIT
https://doi.org/10.21292/2075-1230-2017-95-6-30-35
Abstract
591 lethal cases among patients of TB dispensary were analyzed with relevance to gender and HIV status; the part of patients with TB/HIV co-infection made 38.4% with absolute prevalence of men among those died (82.2%). It has been found out that those died due to HIV infection suffered mostly from disseminated and miliary tuberculosis and HIV negative patients had fibrous cavernous and infiltrate tuberculosis. No impact of gender on the form of pulmonary tuberculosis was detected in HIV positive patients, and infiltrate form of tuberculosis was confidently the most common cause of death in female HIV negative patients. Generalized tuberculosis confidently developed more often in HIV positive patients, male patients had more severe lesions with the higher frequency of meningocephalites. The cause of death in those with TB/HIV infection was the progressing disease with no antiretroviral therapy in the majority of cases regardless of gender.
About the Authors
L. V. PuzyrevаRussian Federation
Larisa V. Puzyreva - Candidate of Medical Sciences, Assistant of Infections Diseases Department.
12, Lenina St., Omsk, 644043, Phone: +7 (3812) 40-45-20
A. V. Mordyk
Russian Federation
Anna V. Mordyk - Doctor of Medical Sciences, Associate Professor, Head of Phthisiology and Phthisiosurgery Department.
12, Lenina St., Omsk, 644043, Phone: +7 (3812) 65-30-15
S. A. Rudenko
Russian Federation
Sergey A. Rudenko - Candidate of Medical Sciences, Head Doctor.
8A, Khimikov St., Omsk, 644050, Phone: +7 (3812) 40-45-20
N. N. Rusаnovа
Russian Federation
Natalya N. Rusanova - Head of Respiratory Tuberculosis Department no. 4.
8A, Khimikov St., Omsk, 644050, Phone: +7 (3812) 40-45-20
V. V. Аntropovа
Russian Federation
Viktoria V. Antropova - Head of Respiratory Tuberculosis Department no. 4.
8A, Khimikov St., Omsk, 644050, Phone: +7 (3812) 40-45-20
A. A. Pugаchev
Russian Federation
Alexander A. Pugachev - Candidate of Medical Sciences, Head of Surgery Department.
8A, Khimikov St., Omsk, 644050, Phone: +7 (3812) 40-45-20
References
1. Gavrilenko V.V., Kochkin А.V., Filippova T.P. Factors providing impact on mortality in those suffering from HIV-associated respiratory tuberculosis. Sib. Med. Journal, 2011, vol. 105, no. 6, pp. 191-192. (In Russ.)
2. Dovgopolyuk E.S., Levakhina L.I., Puzyreva L.V., Mordyk А.V., Tyumentsev А.T., Safonov А.D. Prevalence and outcomes of TB and HIV co-infection in Siberial Federal District from 2010 to 2014. VICH-Infektsiya i Immunosuprssiya, 2016, vol. 8, no. 1, pp. 89-93. (In Russ.)
3. Dovgopolyuk E.S., Puzyreva L.V., Safonov А.D., Mordyk А.V., Tyumentsev А.T., Levakhina L.I. HIV infection epidemic in Siberian Federal District in 2014. JMEI, 2016, no. 2, pp. 37-41. (In Russ.)
4. Ermak T.N., Kravchenko А.V., Shakhgildyan V.I., Kanestri V.G., Ladnaya N.N., Yurin O.G. Analysis of causes of death in HIV patients in the Russian Federation. Epidemiologiya i Infektsionnye Bolezni, 2010, no. 3, pp. 19-22. (In Russ.)
5. Zyuzya Yu.R., Zimina V.N., Batyrov F.А., Kravchenko А.V., Vasilieva I.А. Causes of lethal outcomes in new tuberculosis patients with concurrent HIV infection. Tuberculosis and Lung Diseases, 2011, no. 4, pp. 158-159. (In Russ.)
6. Mordyk А.V., Puzyryova L.V., Sitnikova S.V., Ivanova O.G. Tuberculosis with concurrent HIV-infection in Omsk Region from 2008 to 2012. VICH-Infektsiya i Immunosuprssiya, 2014, vol. 6, no. 2, pp. 106-110. (In Russ.)
7. Nechaeva O.B., Odintsov V.E. Epidemic situation of tuberculosis and HIV-infection in the Russian penitentiary system.Tuberculosis and Lung Diseases, 2015, no. 3, pp. 36-41. (In Russ.)
8. Osnovnye pokazateli protivotuberkuleznoy deyatelnosti v Sibirskom i Dalnevostochnom federalnykh okrugakh. [Main rates of anti-tuberculosis activities in Siberian and Far Eastern Federal Districts]. Novosibirsk, Sibmedizdat NGMU Publ., 2016, 92 p.
9. Puzyreva L.V., Safonov А.D., Nazarova O.I., Аntipova T.V., Fursevich L.N., Zelenov А.V., Musin M.А., Balabokhina M.V., Verbanov А.V. Main clinical causes of lethal outcomes in HIV infected patients in Omsk Region in 2012-2015. VICH-Infektsiya i Immunosuprssiya, 2016, vol. 8, no. 3, pp. 59-64. (In Russ.)
10. Frolova O.P., Schukina I.V., Novoselova O.А. The problem of socially important infection in the Russian Federation: tuberculosis and HIV infection. Zdorovye – Osnova Chelovecheskogo Potentsiala: Problemy i Puti ikh Resheniya, 2012, vol. 7, no. 2, pp. 804-805. (In Russ.)
11. Lot F., Pinget R., Cazein F., Pillonel J., Leclerc M., Haguy H., Benyelle L., Couturier S. Frequency and risk factors for tuberculosis as an AIDS-defining illness, in France. Bull. Epidémiol. Hebdomadaire, 2009, no. 12-13, pp. 110-113.
Review
For citations:
Puzyrevа L.V., Mordyk A.V., Rudenko S.A., Rusаnovа N.N., Аntropovа V.V., Pugаchev A.A. IMPACT OF HIV INFECTION AND GENDER ON THE MORTALITY IN THE PATIENTS OF TUBERCULOSIS IN-PATIENT UNIT. Tuberculosis and Lung Diseases. 2017;95(6):30-35. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-6-30-35