DIFFERENTIAL DIAGNOSTICS OF TUBERCULOSIS AND MYCOBACTERIOSIS IN HIV PATIENTS
https://doi.org/10.21292/2075-1230-2017-95-10-47-52
Abstract
The article analyzes the differences in clinical and laboratory manifestations of tuberculosis and mycobacteriosis in HIV patients. It was found out that mycobacteriosis developed mostly in the socially well patients at the advanced stages of HIV infection. In case of mycobacteriosis, lesions were mostly located in the abdomen with limited inflammation in the chest, while in case of tuberculosis pulmonary lesions dominated. A negative result of sputum PCR assays for tuberculosis mycobacteria with a positive result of the test for AFB is an important sign for differential diagnostics. The obtained results allow performing differential diagnostics of these diseases in those HIV infected.
About the Authors
A. M. Panteleev
Pavlov First Saint Petersburg State Medical University;
Municipal Tuberculosis Hospital no. 2
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of TB/HIV Co-infection Department,
93, Toraza Ave., St. Petersburg, 194214
O. V. Nikulina
Municipal Tuberculosis Hospital no. 2
Russian Federation
Russian Federation
Infectious Diseases Doctor of TB/HIV Co-infection Department,
93, Toraza Ave., St. Petersburg, 194214
A. S. Khristusev
Municipal Tuberculosis Hospital no. 2
Russian Federation
Russian Federation
Infectious Diseases Doctor of TB/HIV Co-infection Department,
93, Toraza Ave., St. Petersburg, 194214
M. S. Dracheva
Municipal Tuberculosis Hospital no. 2
Russian Federation
Russian Federation
Phthisiologist of TB/HIV Co-infection Department,
93, Toraza Ave., St. Petersburg, 194214
O. S. Sokolova
Municipal Tuberculosis Hospital no. 2
Russian Federation
Russian Federation
Phthisiologist of TB/HIV Co-infection Department,
93, Toraza Ave., St. Petersburg, 194214
A. V. Zonova
Municipal Tuberculosis Hospital no. 2
Russian Federation
Russian Federation
Phthisiologist of TB/HIV Co-infection Department,
93, Toraza Ave., St. Petersburg, 194214
References
1. Zyuzya Yu.R., Parkhomenko Yu.G., Zimina V.N., Аlvares Figeroa M.V. Morphological verification of HIV-associated mycobacteriosis caused by non-tuberculous mycobacteria of Myc. Avium complex. Klinicheskaya i Eksperimentalnaya Morfologiya, 2015, vol. 3, no. 15, pp. 11-21. (In Russ.)
2. Mikhajlovskiy А.M., Churkin S.А., Pashkova N.А., Lepekha L.N. Frequency of detection and specific morphology of non-tuberculous mycobacteriosis in those at the advanced stages of HIV infection (as per the data from Orenburg Region). Tuberculosis and Lung Diseases, 2016, vol. 94, no. 12, pp. 57-61. (In Russ.)
3. Panteleev А.M., Dracheva M.S., Nikulina O.V., Sokolova O.S., Zonova А.V. Specific clinical and laboratory features of mycobacteriosis in HIV patients. Journal Infektologii, 2016, vol. 8, no. 3, pp. 40-45. (In Russ.)
4. Benson C.A. Disease due to the Mycobacterium avium complex in patients with AIDS: epidemiology and clinical syndrome. Clin. Infect. Dis., 1994, vol. 18, suppl. 3, pp. 218-822.
5. Edmonson B.C., Morris W.R., Osborn F.D. Bartonella quintana coinfection with Mycobacterium avium complex and CMV in an AIDS patient: case presentation. Clin. Infectious Diseases, 2004, vol. 38, no. 3, pp. 461-463.
6. Griffith D.E., Aksamit T., Brown-Elliott B.A., Catanzaro A., Daley C., Gordin F., Holland S.M., Horsburgh R., Huitt G., Iademarco M.F., Iseman M., Olivier K., Ruoss S., von Reyn C.F., Wallace RJ.Jr, Winthrop K. ATS Mycobacterial Diseases Subcommittee, American Thoracic Society, Infectious Disease Society of America. 2007. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am. J. Respir. Crit. Care Med., no. 175, pp. 367-416. doi:10.1164/rccm.200604-571ST.
7. Hedjazi A., Hosseini M., Hoseinzadeh A. Lymph node co-infection of mycobacterium avium complex and cytomegalovirus in an acquired immunodeficiency syndrome patient. Infect. Dis. Rep., 2013, vol. 22, no. 5(1):e2. doi: 10.4081/idr.2013.e2. eCollection 2013.
8. Ratanasuwan W., Techasathit W., Chuenarom V. et al. Infection due to nontuberculous Mycobacterium other than MAC in AIDS patients at Siriraj Hospital during 1998-2000: saprophyte vs pathogen. J. Med. Assoc. Thai., 2002, vol. 85, pp. 886-893.
9. Suwanagool S., Kolladarungkri T., Leelarasamee A. et al. Prolonged fever due to Mycobacterium avium complex (MAC) disease in advanced HIV infection: a public health concern. J. Med. Assoc. Thai., 1998, vol. 81, no. 11, pp. 893-905.
Review
For citations:
Panteleev A.M., Nikulina O.V., Khristusev A.S., Dracheva M.S., Sokolova O.S., Zonova A.V. DIFFERENTIAL DIAGNOSTICS OF TUBERCULOSIS AND MYCOBACTERIOSIS IN HIV PATIENTS. Tuberculosis and Lung Diseases. 2017;95(10):47-52. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-10-47-52
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