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A CLINICAL CASE OF EFFECTIVE TREATMENT OF EXTENSIVE DRUG RESISTANCE TUBERCULOSIS WITH NEW ANTI-TUBERCULOSIS DRUGS

https://doi.org/10.21292/2075-1230-2017-95-12-58-62

Abstract

The article presents a clinical case of effective treatment of a female patient suffering from respiratory tuberculosis with extensive drug resistance. Chemotherapy regimen included 7 drugs, including bedaquiline and perchlozon.

About the Authors

M. V. Pаvlovа
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Maria V. Pavlova – Doctor of Medical Sciences, Professor, Leading Researcher. 

2/4, Ligovsky Ave., St. Petersburg, 191036




E. S. Ershovа
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Elena S. Ershova – Post-Graduate Student.

2/4, Ligovsky Ave., St. Petersburg, 191036




N. V. Sаpozhnikovа
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Nadezhda V. Sapozhnikova – Candidate of Medical Sciences, Senior Researcher. 

2/4, Ligovsky Ave., St. Petersburg, 191036




A. A. Stаrshinovа
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Anna A. Starshinova – Doctor of Medical Sciences, Senior Researcher. 

2/4, Ligovsky Ave., St. Petersburg, 191036




L. I. Аrchаkovа
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Liudmila I. Archakova – Doctor of Medical Sciences, Head of Medical Unit,
Head of Department for Respiratory Tuberculosis Treatment 

2/4, Ligovsky Ave., St. Petersburg, 191036





I. V. Chernokhаevа
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation

Irina V. Chernokhaeva – Junior Researcher. 

2/4, Ligovsky Ave., St. Petersburg, 191036




References

1. Borisov S.E., Ivanushkina T.N., Ivanova D.А., Filippov А.V., Litvinova N.V., Rodina O.V., Garmash Yu.Yu., Safonova S.G., Bogorodskaya E.M. Efficiency and safety of six month treatment regimens with bedaquiline in the chemotherapy of respiratory tuberculosis patients. Tuberkulez i Sotsialno-Znachimye Zabolevaniya, 2015, no. 3, pp. 30-40. (In Russ.)

2. Morozova T.I., Otpukshhennikova O.I., Doktorova N.P., Danilov А.N. Experience of using bedaquiline for treatment of tuberculosis patients with drug resistance. Tuberculosis and Lung Diseases, 2016, no. 2, pp. 29-35. (In Russ.)

3. Federalnye klinicheskie rekomendatsii po diagnostike i lecheniyu tuberkuleza organov dykhaniya s mnozhestvennoy i shirokoy lekarstvennoy ustojchivostyu. [Federal clinical recommendations for diagnosis and treatment of respiratory tuberculosis with multiple and extensive drug resistance]. Vasilyeva I.А., Аksenova V.А., Ergeshov А.E., Maryandyshev А.O., Samoylova А.P., Bagdasaryan T.R., Komissarova O.G., Lovacheva O.V., Perfilyev А.V.et al. Moscow, Tver, OOO Izdatelstvo Triada Publ., 2014, 72 p.

4. Federalnye klinicheskie rekomendatsii po diagnostike i lecheniyu tuberkuleza organov dykhaniya. [Federal recommendations for diagnostics and treatment of respiratory tuberculosis]. Moscow, New Terra Publ., 2016, 49 p.

5. Chernokhaeva I.V., Pavlova M.V., Starshinova А.А., Belyaeva E.N., Sapozhnikova N.V., Gavrilov P.V., Zhuravlev V.Yu., Аrchakova L.I., Yablonsky P.K. Therapy efficiency of respiratory tuberculosis with multiple drug resistance when using thioureideiminomethyliiridine perchlorate (perchlozon). Prakticheskaya Meditsina, 2015, vol. 1, no. 1-3 (88), pp. 81-85. (In Russ.)

6. Diacon A.H., Pym A., Grobusch M.P., de los Rios J.M., Gotuzzo E., Vasilyeva I., Leimane V., Andries K., Bakare N., de Marez T., Haxaire-Theeuwes M., Lounis N., Meyvisch P., de Paepe E., van Heeswijk R. P., Dannemann B. Multidrug-resistant tuberculosis and culture conversion with Bedaquiline. N. Engl. J. Med., 2014, vol. 371, no. 8, pp. 723-732.


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For citations:


Pаvlovа M.V., Ershovа E.S., Sаpozhnikovа N.V., Stаrshinovа A.A., Аrchаkovа L.I., Chernokhаevа I.V. A CLINICAL CASE OF EFFECTIVE TREATMENT OF EXTENSIVE DRUG RESISTANCE TUBERCULOSIS WITH NEW ANTI-TUBERCULOSIS DRUGS. Tuberculosis and Lung Diseases. 2017;95(12):58-62. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-12-58-62

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)