EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION
https://doi.org/10.21292/2075-1230-2018-96-6-45-50
Abstract
The article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based on sputum conversion criteria: sputum microscopy – 86.7% (13/15; 95% CI 62.1-96.3%), culture ‒ 82.6%, (19/23; 95% CI 62.7-93.0%), and cavity healing ‒ 73.9% (17/23; 95% CI 53.6-87.5%), of them patients with previous treatment failure made 43.6% (10/23). The best outcomes were achieved in the patients with new tuberculosis and relapses. A satisfactory safety profile was demonstrated during this trial piloting chemotherapy regimens containing bedaquiline, no cardiac toxicity was registered.
About the Authors
L. Yu. Tikhonova
Amur Regional TB Dispensary
Russian Federation
Russian Federation
Deputy Head Doctor for Medical Activities,
5, Liteynaya St., Blagoveschensk, Amur Region, 675000
V. V. Sokolova
Amur Regional TB Dispensary
Russian Federation
Russian Federation
Phthisiologist of Therapy Department no. 1,
5, Liteynaya St., Blagoveschensk, Amur Region, 675000
I. A. Tarasyuk
Amur Regional TB Dispensary
Russian Federation
Russian Federation
Head of Therapy Department no. 2,
5, Liteynaya St., Blagoveschensk, Amur Region, 675000
A. M. Ekimenko
Amur Regional TB Dispensary
Russian Federation
Russian Federation
Phthisiologist,
5, Liteynaya St., Blagoveschensk, Amur Region, 675000
M. A. Cherenkova
Amur Regional TB Dispensary
Russian Federation
Russian Federation
Phthisiologist,
5, Liteynaya St., Blagoveschensk, Amur Region, 675000
D. A. Kudlay
Professional Development Institute by the Russian Federal Medical Biological Agency
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor of Healthcare Economy and Marketing Department,
Build. 1, 15, Gamaleya St., Moscow, 123098
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Review
For citations:
Tikhonova L.Yu., Sokolova V.V., Tarasyuk I.A., Ekimenko A.M., Cherenkova M.A., Kudlay D.A. EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION. Tuberculosis and Lung Diseases. 2018;96(6):45-50. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-6-45-50
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