TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION
https://doi.org/10.21292/2075-1230-2018-96-7-5-10
Abstract
The objective: to assess treatment outcomes in tuberculosis patients with extensive drug resistance (XDR TB) treated by new anti-tuberculosis drugs in the civilian community of Arkhangelsk Region.
The analysis included all cases of XDR TB registered in the civilian community of Arkhangelsk Region from November 2006 to December 2013; treatment outcomes were assessed in 21 patients who were treated by regimens containing new anti-tuberculosis drugs (bedaquiline, delamanid, linezolid, clofazimine, imipenem with amoxiclav). 16 patients were treated by regimens containing 4 new anti-tuberculosis drugs. 2 patients were treated by regimen IV containing two drugs – bedaquiline, linezolid and bedaquiline, clofazimine; and 3 patients with regimens containing bedaquiline only.
From November 2006 to December 2017, 175 XDR TB patients were registered in Arkhangelsk Region. The effective chemotherapy using new drugs made 57%, and mortality made 4.7%. In-take of new anti-tuberculosis drugs was accompanied side effects of minor and moderate degree.
New anti-tuberculosis drugs are to be studied further in order to work out the most effective regimens for treatment of XDR TB patients.
About the Authors
Anastasiya I. Gayda
Northern State Medical University
Russian Federation
Russian Federation
Assistant of Phthisiopulmonology Department.
51, Troitsky Ave., Arkhangelsk, 163000
Oksana M. Sveshnikova
Arkhangelsk Clinical TB Dispensary
Russian Federation
Russian Federation
Deputy Chief Doctor.
28, Novgorodsky Ave., Arkhangelsk, 163002
Viktoriya N. Verkhovaya
Arkhangelsk Clinical TB Dispensary
Russian Federation
Russian Federation
Medical Doctor
28, Novgorodsky Ave., Arkhangelsk, 163002
Svetlana V. Makhmaeva
Arkhangelsk Clinical TB Dispensary
Russian Federation
Russian Federation
Head of Department.
28, Novgorodsky Ave., Arkhangelsk, 163002
Elena I. Nikishova
Northern State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor of Phthisiopulmonology Department.
51, Troitsky Ave., Arkhangelsk, 163000
Andrey O. Maryandyshev
Northern State Medical University
Russian Federation
Russian Federation
Correspondent Member of RAMS, Professor, Head of Phthisiopulmonology Department.
51, Troitsky Ave., Arkhangelsk, 163000
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For citations:
Gayda A.I., Sveshnikova O.M., Verkhovaya V.N., Makhmaeva S.V., Nikishova E.I., Maryandyshev A.O. TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION. Tuberculosis and Lung Diseases. 2018;96(7):5-10. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-7-5-10
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