SURGICAL TREATMENT OF TUBERCULOSIS IN HIV PATIENTS
https://doi.org/10.21292/2075-1230-2018-96-7-18-24
Abstract
The objective of the study: to study the outcomes of surgical treatment of tuberculosis in HIV patients.
Subjects and methods. Surgery outcomes in 345 HIV patients with respiratory tuberculosis were analyzed; totally, 355 surgeries were performed on them. Minor surgeries (189/355; 53.2%) done due to emergency reasons were performed in 181 patients, mostly in those with severe immune suppression. 164 patients had planned surgeries (166/355; 46.8%) mostly due to tuberculosis and its complications.
Results. In 345 operated patients, post-operative complications related to surgery made 2.0%, complications not related directly to surgery made 1.2%, and lethal outcomes made 0.9%. Surgery resections were successful even in the patients receiving no antiretroviral therapy with severe immune suppression. All 3 lethal outcomes occurred in the patients with CD4+ count below 200 cell/mcl and they made 2.3% among such patients.
About the Authors
Mikhail V. SinitsynRussian Federation
Candidate of Medical Sciences, Deputy Director in Reporting and Statistics.
10, Stromynka St., Moscow, 107014
Nikolay Yu. Virskiy
Russian Federation
Doctor, Chest Surgeon.
3, Barbolina St., Moscow, 107014
Marina V. Tityukhina
Russian Federation
Doctor of Medical Sciences, Head of Department for Gravitational Surgery and Extracorporal Treatment Methods.
3, Barbolina St., Moscow, 107014
Boris G. Barskiy
Russian Federation
Candidate of Medical Sciences, Head of Surgery Department.
3, Barbolina St., Moscow, 107014
Tamila I. Abu Arkub
Russian Federation
Thoracic Surgeon of Tuberculosis Surgery Unit
3, Barbolina St., Moscow, 107014
Marina V. Kalinina
Russian Federation
Candidate of Medical Sciences, Phthisiologist of Tuberculosis Surgery Department.
3, Barbolina St., Moscow, 107014
References
1. Bogorodskaya E.M., Sinitsyn M.V., Belilovsky E.M., Borisov S.E., Kotova E.А. Impact of HIV infection on the structure of new tuberculosis cases detected in the city of Moscow. Tuberculosis and Lung Diseases, 2017, vol. 95, no. 10, pp. 17-26. (In Russ.)
2. Vasilyeva I.А., Belilovsky E.M., Borisov S.E., Sterlikov S.А., Sinitsyn M.V. Tuberculosis with concurrent HIV infection in the Russian Federation and the world. Tuberculosis and Lung Diseases, 2017, vol. 95, no. 9, pp. 8-18. (In Russ.)
3. Koretskaya N.M., Elyart V.F., Yanovskiy А.V. et al. Surgical treatment of pulmonary tuberculosis in HIV positive patients in the penitentiary system: specific features in pre- and post-operative patients. Tuberculosis and Lung Diseases, 2016, vol. 94, no. 12, pp. 53-54. (In Russ.) Doi: 10.21292/2075-1230-2016-94-12-53-56.
4. Maltsev R.V., Matrosov M.V., Reshetnikov M.N., Аntipov А.G., Lovacheva O.V. Endoscopic treatment of bronchoesophageal fistula in tuberculosis of chest lymph nodes in HIV patients. Tuberculosis and Lung Diseases, 2012, no. 5, pp. 60-65. (In Russ.)
5. Panteleev А.M., Basek T.S., Nikulina O.V. Safety of surgical method of chest tuberculosis treatment in HIV patients. Tub. i Sots. Znach. Zabolevaniya, 2014, no. 1-2, pp. 18-20. (In Russ.)
6. Sinitsyn M.V., Reshetnikov M.N., Sokolina I.А., Plotkin D.V., Virskiy N.Yu., Barskiy B.G. Diagnostics of chest diseases in HIV patients using video-assisted endosurgical technologies. Endoskopicheskaya Khirurgiya, 2017, vol. 33, no. 2, pp. 17-22. (In Russ.)
7. UNAIDS. Informatsionny byulleten za 2017 god. (Russ. version: Fact sheet – Latest statistics on the status of the AIDS epidemic, 2017). http://www.unaids.org/ru/resources/fact-sheet
8. Calligaro G., Moodley L., Symons G., Dheda K. The medical and surgical treatment of drug-resistant tuberculosis. J. Thora, Dis., 2014, vol. 6, no. 3, pp. 186-195. https://doi.org/10.3978/j.issn.2072-1439.2013.11.11
9. Getahun H., Gunneberg C., Granich R., Nunn P. HIV infection-associated tuberculosis: The epidemiology and the response. Clin. Infect. Dis., 2010, vol. 50, pp. S201-S207. https://doi.org/10.1086/651492
10. Global tuberculosis report 2016. Geneva, World Health Organization, 2016/ http://www.who.int/tb/publications/ru/
11. Harris et al. The effect of surgery on the outcome of treatment for multidrug-resistant tuberculosis: a systematic review and metaanalysis. BMC Infect. Diseases, 2016, vol. 16, pp. 262 https://doi.org/10.1186/s12879-016-1585-0
12. Marrone M. T., Venkataramanan V., Goodman M. et al. Surgical interventions for drug-resistant tuberculosis: a systematic review and meta-analysis. Int. J. Tuberc. Lung Dis., 2013, vol. 17, pp. 6-16. https://doi.org/10.5588/ijtld.12.0198
13. Nagasaka S., Yazaki H., Ito H., Ok S., Kuwata H., Seike A., Kitazawa S., Fukuda S., Hosaka S. Effect of CD4+ T-lymphocyte count on hospital outcome of elective general thoracic surgery patients with human immunodeficiency virus. Gener. Thorac. Cardiovasc. Surgery, 2011, vol. 59, no. 11, pp. 743-747. doi: 10.1007/s11748-011-0808-y
Review
For citations:
Sinitsyn M.V., Virskiy N.Yu., Tityukhina M.V., Barskiy B.G., Abu Arkub T.I., Kalinina M.V. SURGICAL TREATMENT OF TUBERCULOSIS IN HIV PATIENTS. Tuberculosis and Lung Diseases. 2018;96(7):18-24. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-7-18-24