CHANGES IN THE COURSE OF TUBERCULOSIS IN THE PATIENTS WITH DIFFERENT PSYCHOLOGICAL STATUS
https://doi.org/10.21292/2075-1230-2018-96-7-33-38
Abstract
The objective of the study: to investigate the changes in the course of tuberculosis in the patients with different psychological status.
Subjects and methods. The changes in the course of tuberculosis were studied in 249 new pulmonary tuberculosis patients who had in-patient treatment in CTRI. The groups within the study were formed basing on the results of psychological status assessment: Group 1 included patients with favorable psychological status (171; 68.7% of patients) and Group 2 included patients with different psychological disorders (78; 31.3% of patients) (p < 0.001). Among patients from Group 2 women (66; 84.6%) significantly prevailed over men (12; 15.4%) (< 0.001).
Results. It has been found out that groups with different psychological status did not confidently differ in their clinical and X-ray signs before the treatment start. Whereby, in patients from Group 2 versus patients from Group 1, the abnormalities in the results of laboratory tests were registered confidently more often (87.2 versus 75.4% cases) (p < 0.05), as well as multiple drug resistance (58 versus 41.4% of cases) (p < 0.05). The frequency of adverse events caused by anti-tuberculosis drugs was higher in Group 2 versus Group 1 (25; 32.1% and 28; 16.4% of cases) (p < 0.05). After management of adverse events, the number of patients with poor tolerance was still confidently higher in Group 2 (14; 17.9% of cases), compared to Group 1 (11; 6.4%) (p < 0.05). It was found out that the efficiency of in-patient treatment did not confidently differ in the patients with different psychological status.
About the Authors
Natalya V. Zolotova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Physiological Sciences, Senior Researcher of the Group Studying Psychological Problems Related to Tuberculosis, Children and Adolescents Department.
2, Yauzskaya Alleya, Moscow, 107564
Galina V. Baranova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Physiological Sciences, Senior Researcher of the Group Studying Psychological Problems Related to Tuberculosis, Children and Adolescents Department.
2, Yauzskaya Alleya, Moscow, 107564
Vladimir V. Streltsov
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Physiological Sciences, Senior Researcher of the Group Studying Psychological Problems Related to Tuberculosis, Children and Adolescents Department.
2, Yauzskaya Alleya, Moscow, 107564
Nadezhda Yu. Kharitonova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Medical Psychologist of the First Therapy Department of Phthisiology Unit.
2, Yauzskaya Alleya, Moscow, 107564
Tatevik R. Bagdasaryan
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of First Therapy Department of Phthisiology Unit.
2, Yauzskaya Alleya, Moscow, 107564
Anzhela S. Polyakova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Phthisiologist of the First Therapy Department of Phthisiology Unit
2, Yauzskaya Alleya, Moscow, 107564
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Review
For citations:
Zolotova N.V., Baranova G.V., Streltsov V.V., Kharitonova N.Yu., Bagdasaryan T.R., Polyakova A.S. CHANGES IN THE COURSE OF TUBERCULOSIS IN THE PATIENTS WITH DIFFERENT PSYCHOLOGICAL STATUS. Tuberculosis and Lung Diseases. 2018;96(7):33-38. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-7-33-38
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