Assessment of effectiveness of the empiric treatment regimen in tuberculosis patients suspected with multiple drug resistance in the Russian Federation
https://doi.org/10.21292/2075-1230-2018-96-11-28-33
Abstract
The article presents the comparative assessment of effectiveness of tuberculosis treatment with empiric chemotherapy regimen IV. The outcomes of treatment with empiric regimen IV of the cases in whom later drug resistance was confirmed were compared with the outcomes of regimen IV prescribed to the patients who had confirmed resistance at least to rifampicin. The outcomes of empiric treatment with regimen IV in the cases without confirmed resistance to rifampicin were compared to outcomes of treatment with regimens I, II, and III, prescribed to those sensitive to rifampicin. No statistically significant differences in the number of favorable treatment outcomes were found which allows concluding that it is advisable to prescribe empiric regimen IV if multiple drug resistant tuberculosis is suspected.
About the Authors
Sergey A. Sterlikov
Central Research Institute for Public Health Organization and Informatization
Russian Federation
Doctor of Medical Sciences, Deputy Head of Federal Center for Tuberculosis Control in the Russian Federation.
11, Dobrolyubova St., Moscow, 127254
Russian Federation
Doctor of Medical Sciences, Deputy Head of Federal Center for Tuberculosis Control in the Russian Federation.
11, Dobrolyubova St., Moscow, 127254
Anastasiya G. Samoylova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Doctor of Medical Sciences, Deputy Director for Research.
Build. 2, 4, Dostoevsky St., Moscow, 127473
Russian Federation
Doctor of Medical Sciences, Deputy Director for Research.
Build. 2, 4, Dostoevsky St., Moscow, 127473
Vadim V. Testov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Doctor of Medical Sciences, Acting Director of Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases,
50, XXII Parts"ezda St., Yekaterinburg, Sverdlovsk Region, 620039
Build. 2, 4, Dostoevsky St., Moscow, 127473;
Russian Federation
Doctor of Medical Sciences, Acting Director of Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious Diseases,
50, XXII Parts"ezda St., Yekaterinburg, Sverdlovsk Region, 620039
Build. 2, 4, Dostoevsky St., Moscow, 127473;
Konstantin A. Glebov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Researcher
Build. 2, 4, Dostoevsky St., Moscow, 127473
Russian Federation
Researcher
Build. 2, 4, Dostoevsky St., Moscow, 127473
Irina A. Vasilyeva
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Doctor of Medical Sciences, Professor, Director.
Build. 2, 4, Dostoevsky St., Moscow, 127473
Russian Federation
Doctor of Medical Sciences, Professor, Director.
Build. 2, 4, Dostoevsky St., Moscow, 127473
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For citations:
Sterlikov S.A., Samoylova A.G., Testov V.V., Glebov K.A., Vasilyeva I.A. Assessment of effectiveness of the empiric treatment regimen in tuberculosis patients suspected with multiple drug resistance in the Russian Federation. Tuberculosis and Lung Diseases. 2018;96(11):28-33. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-11-28-33
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