Burden of tuberculosis and TB/HIV co-infection in Dushanbe
https://doi.org/10.21292/2075-1230-2021-99-2-40-44
Abstract
The objective of the study: to determine the burden of tuberculosis with concurrent HIV infection in Dushanbe and the prevalence of multiple drug resistant tuberculosis, to assess the treatment efficacy of drug susceptible and drug resistant tuberculosis depending on the HIV status of patients.
Subjects: A cohort retrospective study was carried out assessing results of examination and treatment of all patients (1,838 people) registered for tuberculosis treatment from 01.06.2016 to 25.12.2019 in Dushanbe.
Results. Among new tuberculosis cases, MDR is more often registered in HIV positive patients versus HIV negative patients (OR 2.3, 95% CI 1.1-4.9, p = 0.03). The chances of successful treatment of tuberculosis in HIV negative patients were higher versus HIV positive patients as well as in drug susceptible tuberculosis (OR 4.7, 95% CI 3.1-7.4; p < 0.000) versus drug resistant tuberculosis (OR 2.5, 95% CI 1.1-75.7; p = 0.03). The chances of tuberculosis cure did not differ statistically significantly among patients with different HIV status for both drug resistant and drug susceptible tuberculosis.
About the Authors
B. P. Pirmakhmadzoda
City Center for Population Protection from Tuberculosis
Tajikistan
Tajikistan
Bobochon P. Pirmakhmadzoda, Director
55 A, Bukhoro St., Dushanbe, 734025
Z. Kh. Tilloeva
City Center for Population Protection from Tuberculosis
Tajikistan
Tajikistan
Zulfia Kh. Tilloeva, Physician, Tuberculosis Infection Control Specialist
55 A, Bukhoro St., Dushanbe, 734025
Kh. S. Sharifzoda
Dushanbe City Health Administration
Tajikistan
Tajikistan
Khushvakht S. Sharifzoda, Head
8, Narzikulova St., Dushanbe, 734025
O. Ya. Kabirov
National Reference Laboratory, National Center of Tuberculosis, Lung Diseases and Thoracic Surgery
Tajikistan
Tajikistan
Olim Ya. Kabirov, Head of National Tuberculosis Reference Laboratory
Shifo Settlement, Vakhdat
K. A. Imomnazarova
City Center for Population Protection from Tuberculosis
Tajikistan
Tajikistan
Karomat A. Imomnazarova, Physician, Specialist Responsible for Tuberculosis and HIV
55 A, Bukhoro St., Dushanbe, 734025
S. M. Odinaeva
City Center for Population Protection from Tuberculosis
Tajikistan
Tajikistan
Suraye M. Odinaeva, Doctor Responsible for Statistics
55 A, Bukhoro St., Dushanbe, 734025
References
1. Vasilyeva I.А., Belilovsky E.M., Borisov S.E., Sterlikov S.А., Sinitsyn M.V. Tuberculosis with concurrent HIV infection in the Russian Federation and the world. Tuberculosis and Lung Diseases, 2017, vol. 95, no. 9, pp. 8-18. (In Russ.) doi: 10.21292/2075-1230-2017-95-9-8-18.
2. Makhmudova R.U., Makhmudova P.U., Zakirova K.А. The problem of early detection of tuberculosis with concurrent HIV infection under current economic situation of the Republic of Tajikistan. Vestnik Avitsenny, 2018, vol. 20, no. 2-3, pp. 240-244. (In Russ.) Epub., Available: https://vestnik-avicenna.tj/upload/global/16_240-244.pdf.
3. Popov S.А., Sabgayda T.P., Radina T.S. Assessment of correlation between HIV infection and tuberculosis with multiple drug resistance. Tuberculosis and Lung Diseases, 2018, vol. 96, no. 7, pp. 25-32. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-7-25-32.
4. Sirodzhidinova U.Yu., Bobokhodzhaev O.I., Dusmatova Z.Sh., Mirzoeva F.O., Pirov K.I., Dzhumaev R.R. Analysis of tuberculosis situation in the Republic of Tajikistan. Tuberculosis and Lung Diseases, 2015, no. 2, pp. 39-45. (In Russ.) https://doi.org/10.21292/2075-1230-2015-0-2-39-45.
5. Chislennost naseleniya Respubliki Tadzhikistan na 1 yanvarya 2019 g. [Population of the Republic of Tajikistan as of January 1, 2019]. Agentstvo Po Statistike Pri Prezidente Respubliki Tadzhikistan Publ., Epub. Available: www.stat.tj.
6. Godinho J., Novotny T., Tadesse H., Vinokur A. 2004. HIV/AIDS and Tuberculosis in Central Asia: Country Profiles. World Bank Working Paper No. 20. Washington, DC: World Bank.
7. Regional Office for Europe W. Regional Committee for Europe 65th Session on Tuberculosis action plan for the WHO European Region 2016-2020. (Internet). cited 2018 Nov 15. Epub. Available: http://www.euro.who.int/en/who-we-are/governance.
8. Surveillance report. Tuberculosis surveillance and monitoring in Europe, 2019. Epub. Available: https://www.ecdc.europa.eu/sites/default/files/documents/tuberculosis-surveillance-monitoring-Europe-2019-20_Mar_2019.pdf.
9. Uplekar M., Weil D., Lonnroth K., Jaramillo E., Lienhardt C., Dias H.M. et al. WHO’s new end TB strategy. The Lancet, 2015. Epub. Available: https://pubmed.ncbi.nlm.nih.gov/25814376/
10. van der Werf M.J., Ködmön C., Zucs P., Hollo V., Amato-Gauci A.J., Pharris A. Tuberculosis and HIV coinfection in Europe: looking at one reality from two angles. AIDS, 2016, vol. 30, no. 18, pp. 2845-2853. doi:10.1097/QAD.0000000000001252. Epub. Available: https://pubmed.ncbi. nlm.nih.gov/27755106/
11. World Health Organization (2018) Tajikistan Tuberculosis country profile. Available: https://worldhealthorg.shinyapps.io/tb_profiles/?_inputs_&lan=%22EN%22&iso2=%22TJ%22&main_tabs=%22est_tab%22. Accessed: 25 July 2020.
Review
For citations:
Pirmakhmadzoda B.P., Tilloeva Z.Kh., Sharifzoda Kh.S., Kabirov O.Ya., Imomnazarova K.A., Odinaeva S.M. Burden of tuberculosis and TB/HIV co-infection in Dushanbe. Tuberculosis and Lung Diseases. 2021;99(2):40-44. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-2-40-44
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