Clinical and statistical analysis of predictors oflethal outcomes in tuberculosis patients treated in medical units of the Russian Federal penitentiary system
https://doi.org/10.21292/2075-1230-2022-100-5-22-27
Abstract
The objective: to determine risk factors of lethal outcomes (predictors) in tuberculosis patients treated with chemotherapy regimens I, II, III during confinement in the Russian penitentiary system.
Subjects and Methods: data on 6,069 patients registered for treatment in 2019 and 2020 were studied. Univariate and multivariate analyses were performed.
Results. The following factors were found to have effect on mortality: age (aOR = 1.05; 95% CI 1.03-1.06), multiple localizations of tuberculosis (aOR = 11.08; 95% CI 5.12-24.20), concurrent HIV infection (aOR = 9.13; 95% CI 6.90-12.24), and positive sputum microscopy at registration (aOR = 5.18; 95% CI 3.93-6.81). The patient gender was found to have no effect (OR = 0.9; 95% CI 0.4-1.9; p = 1).
About the Authors
M. E. Vostroknutov
Research Institute of the Federal Penitentiary System
Russian Federation
Russian Federation
Mikhail E. Vostroknutov, Candidate of Medical Sciences, Senior Researcher
SPIN: 8375-8998
14, Zhitnaya St., GSP-1, Moscow, 119991
S. A. Sterlikov
Russian Research Institute of Health
Russian Federation
Russian Federation
Sergey A. Sterlikov, Doctor of Medical Sciences, Deputy Head of Federal Monitoring Center for Prevention of Tuberculosis Transmission and Program Monitoring in the Russian Federation
SPIN: 8672-4853
11, Dobrolyubova St., Moscow, 127254
V. G. Kudrina
Russian Medical Academy of On-going Professional Education
Russian Federation
Russian Federation
Valentina G. Kudrina, Doctor of Medical Sciences, Professor, Honored Doctor of Russia, Head of Department of Medical Statistics and Digital Health Care
SPIN-code: 8395-2771
19, Belomorskaya St., Moscow, 125445
N. M. Popova
Izhevsk State Medical Academy, Russian Medical Academy
Russian Federation
Russian Federation
Natalya M. Popova, Doctor of Medical Sciences, Professor, Head of Department of Public Health and Health Care
181, Revolyutsionnaya St., Izhevsk, 426034
References
1. Averyanova E.L. Cluster analysis in the study of infectious penitentiary syndrome. Sb. nauch. statey po materialam VI mezhdunarodnoy nauchno-prakticheskoy konferentsii. [Coll. of articles of the VI International Scientific-Practical Conference]. Ufa, Vestnik Nauki Publ., 2021, pp. 106-108. (In Russ.)
2. Otraslevye i ekonomicheskie pokazateli protivotuberkuleznoy raboty v 2019-2020 gg. Analiticheskiy obzor osnovnykh pokazateley i statisticheskiye materialy. [Sectorial and economic rates for TB control in 2019-2020. Analysis of main rates and statistic materials]. Moscow, RIO TSNIIOIZ Publ., 2021, 63 p.
3. Ponomarev S.B., Burt A.A., Dyuzheva E.B. Clinical aspects of the penitentiary stress. Vedomosti Ugolovno-Ispolnitelnoy Sistemy, 2016, no. 4, pp. 29-33. (InRuss.)
4. Saenko S.S., Sterlikov S.A., Rusakova L.I., Lekhleider M.V., Pirogova N.D., Surnacheva I.F., Gudenkov M.A., Svicharskaya A.K., Podgainaya O.A., Kononenko Yu.S., Novikova T.V., Yukhnova E.A., Frolov E.G., Gromov A.V., Gaevaya I.S. Predictors of unfavorable outcomes of tuberculosis cases treated with chemotherapy regimens I, II, III. Vestnik TSNIIT, 2020, no. 3 (12), pp. 24-34. (In Russ.) doi: 10.7868/S2587667820030048.
5. Adane K., Spigt M., Dinat G. uberculosis treatment outcome and predictors innorthern Ethiopian prisons: a five-year retrospective analysis. BMC Pulm. Med., 2018, 18, article number 37. doi: 10.1186/s12890-018-0600-1.
6. Dewan P.K., Argun P.M., Kiryanova H., Kondroshova N.V. Risk factors for death during tuberculosis treatment in Orel, Russia. Int. J. Tub. Lung Dis., 2004, no. 8 (5), pp. 598-602.
7. Lesnic E., Niguleanu A., Ciobanu S., Todoriko L. Predictive factors associated to low tuberculosis treatment outcome: cross sectional study. Moldov. Med. J., 2017, vol. 60, no. 2, pp. 7-12. doi: 10.5281/zenodo.1050982.
8. Makhmudova M., Maxsumova Z., Rajabzoda A., Makhmadov A., van den Hof S., Mirtskhulava V. Risk factors for unfavourable treatment outcomes among rifampicin-resistant tuberculosis patients in Tajikistan. Int. J. Tub. Lung Dis., 2019, vol. 23, no. 3, pp. 331-336. doi: 10.5588/ijtld.18.0311.
9. Singano V., Kip E., Ching’ani W., Chiwaula L. Tuberculosis treatment outcomes among prisoners and general population in Zomba, Malawi. BMC Public Health, 2020, no. 20, article number 700. doi: 10.1186/s12889-020-08841-z.
10. Skrahina A., Hurevich H., Zalutskaya A., Sahalchyk E., Astrauko A., HoffnerS., Rusovich V., Dadu A., Colombani P., Dara M., Gemert W., Zignole M. Multidrug-resistant tuberculosis in Belarus: the size of the problem and associated risk factors. Bull World Health Organ., 2013, no. 91 (1), pp. 36-45. doi: 10.2471/BLT.12.104588.
Review
For citations:
Vostroknutov M.E., Sterlikov S.A., Kudrina V.G., Popova N.M. Clinical and statistical analysis of predictors oflethal outcomes in tuberculosis patients treated in medical units of the Russian Federal penitentiary system. Tuberculosis and Lung Diseases. 2022;100(5):22-27. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-5-22-27
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