Prognosis of the Course of Chronic Obstructive Pulmonary Disease with Obstructive Sleep Apnea-Hypopnea Syndrome
https://doi.org/10.21292/2075-1230-2022-100-7-22-27
Abstract
The objective: to evaluate the prognosis of 4-year survival in patients with chronic obstructive pulmonary disease (COPD) and concomitant obstructive sleep apnea-hypopnea syndrome (OSAHS).
Subjects and Methods. 62 patients with COPD and OSAHS were enrolled in the study, they all had been diagnosed in accordance with the recommendations of GOLD (2017). The clinical and functional examination included assessment of respiratory function parameters and a 6-minute step test, a survey using the validated questionnaire of the dyspnea scale by Medical Research Council (MRC) followed by the calculation of body mass index and the BODE index.
Results. Patients with COPD and concomitant OSAHS demonstrated higher intensity of dyspnea, deterioration of functional obstructive disorders, and lower exercise tolerance. The course of the disease was characterized by multiple exacerbations requiring hospitalization, 77.4% of COPD patients with OSAHS suffered from cardiovascular diseases and 95.2% were obese. Evaluation of the integral BODE index in COPD patients with OSAHS showed that only 35.5% of them had a 4-year survival rate exceeding 57%. A strong inverse correlation was established between the BODE index and the maximum desaturation rate (r = -0.78) and the moderate inverse correlation was established between the BODE index and SaO2 (r = -0.37). As a result of a 12-year follow-up (2008-2019), mortality in COPD patients with OSAHS was established in 22.2% of cases, mainly among COPD patients with severe OSAHS.
About the Authors
Kh. S. Razhabov
Republican Special Scientific Practical Medical Center of Phthisiology and Pulmonology
Uzbekistan
Uzbekistan
Khayrillo S. Razhabov, Doctoral Student
1, Mazhlisiy St., Shaykhantakhurskiy District, Tashkent, 100086
Phone: +99871-278-04-70
I. V. Liverko
Republican Special Scientific Practical Medical Center of Phthisiology and Pulmonology
Uzbekistan
Uzbekistan
Irina V. Liverko, Deputy Director for Research
1, Mazhlisiy St., Shaykhantakhurskiy District, Tashkent, 100086
Phone: +99871-278-04-70
References
1. Bekker K.N., Mishlanov V.Yu., Katkova A.V., Koshurnikova E.P., Syromyatnikova L.I. Cardiovascular disease morbidity rate in patients with different chronic obstructive pulmonary disease phenotypes. Vestnik Sovremennoy Klinicheskoy Meditsiny, 2019, no. 12, pp. 24-30. (In Russ.)
2. Kondratski D.P., Martynyuk K.I., Pisarenko S.V. Chronic obstructive pulmonary disease as a cause of temporary disability. XXIV Natsionalny Kongress po boleznyam organov dykhaniya. Sbornik tezisov, 2019. [The XXIVth National Congress on Respiratory Diseases. Abst. Book, 2019]. 201, pp. 164-165. (In Russ.)
3. Pisarenko N.K., Kondratski D.P., Pisarenko S.V. COPD as a component of noncommunicable diseases and a cause of death. XXIV Natsionalny Kongress po boleznyam organov dykhaniya. Sbornik tezisov, 2019. [The XXIVth National Congress on Respiratory Diseases. Abst. Book, 2019]. 200, pp. 163-164. (In Russ.)
4. Tseimakh I.Ya., Shoikhet Ya.N. Thrombogenic risk factors in patients with chronic obstructive pulmonary disease with concurrent obstructive sleep apnea syndrome in the period after exacerbation. XXIV Natsionalny Kongress po boleznyam organov dykhaniya. Sbornik tezisov, 2019. [The XXIVth National Congress on Respiratory Diseases. Abst. Book, 2019]. 179, pp. 147-148. (In Russ.)
5. Axson E. L., Bottle A., Cowie M. R., Quint J. K. Relationship between heart failure and the risk of acute exacerbation of COPD // Thorax. ‒ 2021. ‒ Vol. 76, № 8. ‒ Р. 807-814.
6. Axson E. L., Sundaram V., Bloom C. I., Bottle A., Cowie M. R., Quint J. K. Temporal trends in the incidence of heart failure among patients with chronic obstructive pulmonary disease and its association with mortality // Ann. Am. Thorac. Soc. ‒ 2020. ‒ Vol. 17, № 8. ‒ Р. 939-948.
7. Barnes P. J. Endo-phenotyping of COPD patients // Expert. Rev. Respir. Med. 2021. ‒ № 1. ‒ Р. 27-37.
8. Celli B. R. Change in the BODE index reflects disease modification in COPD: lessons from lung volume reduction surgery // Chest. ‒ 2006. ‒ Vol. 129, № 4. P. 873-878.
9. Dal Negro R. W., Carone M., Cuttitta G., Gallelli L., Pistolesi M., Privitera S., Ceriana P., Pirina P., Balbi B., Vancheri C., Gallo F. M., Chetta A., Turco P. Prevalence and clinical features of most frequent phenotypes in the Italian COPD population: the CLIMA Study // Multidiscip. Respir. Med. ‒ 2021. Vol. 16, № 1. ‒ Р. 790.
10. Hizawa N., Fukunaga K., Sugiura H., Nakano Y., Motokazu Kato, Sugiyama Y., Hanazawa T., Kaise T., Tal-Singer R., Jones P. W., Barnes N., Compton C., Ishii T. Prospective cohort study to assess obstructive respiratory disease phenotypes and endotypes in Japan: The TRAIT study design // Int. J. Chron. Obstruct. Pulmon Dis. ‒ 2021. ‒ № 16. ‒ Р. 1813-1822.
11. Hurst J. R., Siddiqui M. K., Singh B., Varghese P., Holmgren U., de Nigris E. A Systematic literature review of the humanistic burden of COPD // Int. J. Chron. Obstruct. Pulmon. Dis. ‒ 2021 . ‒ № 16. ‒ Р. 1303-1314.
12. Ioachimescu O. C., Janocko N. J., Ciavatta M. M., Howard M., Warnock M. V. Obstructive Lung Disease and Obstructive Sleep Apnea (OLDOSA) cohort study: 10-year assessment // J. Clin. Sleep. Med. ‒ 2020. ‒ Vol. 16, № 2. Р. 267-277.
13. Johansson H., Berterö C., Berg K., Jonasson L. L. To live a life with COPD ‒ the consequences of symptom burden // Int. J. Chron. Obstruct. Pulmon. Dis. 2019. ‒ № 14. ‒ Р. 905-909.
14. Kendzerska T., Leung R. S., Aaron S. D., Ayas N., Sandoz J. S., Andrea S. Gershon. Cardiovascular outcomes and all-cause mortality in patients with obstructive sleep apnea and chronic obstructive pulmonary disease (overlap syndrome) // Ann. Am. Thorac. Soc. ‒ 2019. ‒ Vol. 16, № 1. ‒ Р. 71-81.
15. Lazic Z., Stankovic I., Milenkovic B., Zvezdin B., Hromis S., Jankovic S., Cupurdija V. Characteristics of COPD phenotypes in Serbia // Int. J. Chron. Obstruct. Pulmon. Dis. 2021. ‒ № 16. ‒ Р. 643-654.
16. Masror-Roudsary D., Nasrin Fadaee Aghdam, Rafii F., Baha R., Khajeh M., Mardani A. The relationship between experienced respiratory symptoms and health-related quality of life in the elderly with chronic obstructive pulmonary disease // Crit. Care Res. Pract. ‒ 2021. ‒ № 55. ‒ Р. 642-675.
17. Mjid M., Snène H., Hedhli A., Rouhou S.C., Toujani S., Dhahri B.COPD patients' body composition and its impact on lung function // Tunis Med. 2021. ‒ Vol. 99, № 2. ‒ Р. 285-290.
18. Stanford R. H., Engel-Nitz N. M., Bancroft T., Essoi B. The identification and cost of acute chronic obstructive pulmonary disease exacerbations in a united states population healthcare claims database // COPD. ‒ 2020. ‒ Vol. 17, № 5. Р. 499-508.
19. Tang M., Long Y., Liu S., Yue X., Shi T. Prevalence of cardiovascular events and their risk factors in patients with chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome // Front Cardiovasc. Med. ‒ 2021. № 8. doi: 10.3389/fcvm.2021.694806.
20. Yang K., Wu Y., Chen D., Liu S., Chen R. The impact of lung function on extra-pulmonary diseases and all-cause mortality in US adult population with and without COPD // Clin. Epidemiol. ‒ 2020. ‒ № 12. ‒ Р. 997-1005.
Review
For citations:
Razhabov Kh.S., Liverko I.V. Prognosis of the Course of Chronic Obstructive Pulmonary Disease with Obstructive Sleep Apnea-Hypopnea Syndrome. Tuberculosis and Lung Diseases. 2022;100(7):22-27. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-7-22-27
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