Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality?
E. O. Peretsmanas,
E. A. Orlova-Morozova,
I. V. Esin,
G. D. Kaminsky,
T. E. Tyulkova,
A. E. Panova,
O. V. Lovacheva O. V. https://doi.org/10.58838/2075-1230-2023-101-2-47-53
Abstract
The objective: analysis of clinical cases of tuberculous spondylitis in HIV-infected patients with the detection of HIV RNA in the focus of vertebral bodies destruction.
Subjects and Methods. Medical records of 2 HIV-infected patients who underwent surgery for verified tuberculous spondylitis were analyzed. Parts of the vertebral bodies collected during surgery were examined (PCR, microbiological and histological tests), those were parts with destruction and fragments of healthy iliac bone necessary to fill the implant during corporodesis.
Results. RNA HIV was detected in the foci of bone destructionas as well as M. tuberculosis DNA. The viral load in the fragments of healthy iliac bone and peripheral blood of these patients was undetectable.
About the Authors
E. O. Peretsmanas
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow
Russian Federation
Russian Federation
Evgeniy O. Peretsmanas - Head of Research Department of Osteoarticular Pathology, Doctor of Medical Sciences, Honored Doctor of Russia
4, Dostoyevsky St., Moscow, 127473
E. A. Orlova-Morozova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow
Russian Federation
Russian Federation
Elena A. Orlova-Morozova - Candidate of Medical Sciences, Senior Researcher of Infectious Pathology Department
4, Dostoyevsky St., Moscow, 127473
I. V. Esin
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow
Russian Federation
Russian Federation
Igor V. Esin - Candidate of Medical Sciences, Senior Researcher, Head of Research Department of Osteoarticular Pathology
4, Dostoyevsky St., Moscow, 127473
G. D. Kaminsky
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow
Russian Federation
Russian Federation
Grigoriy D. Kaminsky - Head of Infectious Pathology Department, Doctor of Medical Sciences
4, Dostoyevsky St., Moscow, 127473
T. E. Tyulkova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow
Russian Federation
Russian Federation
Tatyana E. Tyulkova - Head of Research Coordination Department, Doctor of Medical Sciences
4, Dostoyevsky St., Moscow, 127473
A. E. Panova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow
Russian Federation
Russian Federation
Anna E. Panova - Candidate of Medical Sciences, Head of Laboratory Diagnostics Department, Head of the Scientific Laboratory of Microbiology, Virology and Molecular Biology Research
4, Dostoyevsky St., Moscow, 127473
O. V. Lovacheva O. V.
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow
Russian Federation
Russian Federation
Olga V. Lovacheva - Doctor of Medical Sciences, Professor, Senior Researcher of Research Department of Differential Diagnosis and Treatment of Tuberculosis and Concurrent Infections
4, Dostoyevsky St., Moscow, 127473
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For citations:
Peretsmanas E.O., Orlova-Morozova E.A., Esin I.V., Kaminsky G.D., Tyulkova T.E., Panova A.E., Lovacheva O. V. O.V. Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality? Tuberculosis and Lung Diseases. 2023;101(2):47-53. (In Russ.) https://doi.org/10.58838/2075-1230-2023-101-2-47-53
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