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Management of Adverse Events during Treatment of Tuberculosis in the Patient with Systemic Lupus Erythematosus

https://doi.org/10.58838/2075-1230-2023-101-4-80-86

Abstract

The article describes a clinical case of chemotherapy for drug susceptible rapidly progressive pulmonary tuberculosis in a patient with systemic lupus erythematosus taking glucocorticosteroids on regular basis. Due to adverse events that occurred when using the regimen of first line drugs, the patient discontinued taking first line drugs and was immediately switched to second line drugs. A timely decision to completely cancel the chemotherapy regimen with first line drugs that caused AE, the immediate start of the individual regimen (Bq, Lzd, Lfx, and Tzd) made it possible to cure pulmonary and bronchial tuberculosis in this patient. At the same time, data were obtained on the effective and safe use of tuberculosis treatment regimen (Bq, Lzd, Lfx, and Tzd) while taking GCS for SLE.

About the Authors

M. I. Romanova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation

Maria I. Romanova - Junior Researcher.

4, Dostoevsky St., Moscow, 127473

Phone: +7 (495) 681-11-66



E. V. Vaniev
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation

Eduard V. Vaniev - Candidate of Medical Sciences, Head of Therapy Department no. 2.

4, Dostoevsky St., Moscow, 127473

Phone: +7 (495) 681-11-66



D. O. Churkin
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation

Denis O. Churkin – Phthisiologist.

4, Dostoevsky St., Moscow, 127473

Phone: +7 (495) 681-11-66



A. V. Abramchenko
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health; Pirogov Russian National Research Medical University, Russian Ministry of Health
Russian Federation

Anna V. Abramchenko - Associate Professor of Phthisiology Department, Junior Researcher of Research Department for Differential Diagnostics and Treatment of Tuberculosis and Concurrent Infections, National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health.

4, Dostoevsky St., Moscow, 127473; 1, Ostrovityanova St., Moscow, 117997

Phone: +7 (495) 681-11-66; +7 (495) 434-22-66



A. I. Gayda
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation

Anastasia I. Gayda - Candidate of Medical Sciences, Junior Researcher.

4, Dostoevsky St., Moscow, 127473

Phone: +7 (495) 681-11-66



O. V. Lovacheva
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation

Olga V. Lovacheva - Doctor of Medical Sciences, Professor, Chief Researcher of Research Department for Differential Diagnostics and Treatment of Tuberculosis and Concurrent Infections.

4, Dostoevsky St., Moscow, 127473

Phone: +7 (495) 681-11-66



A. G. Samoylova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation

Anastasia G. Samoylova - Doctor of Medical Sciences, Deputy Director for Research.

4, Dostoevsky St., Moscow, 127473

Phone: +7 (495) 681-11-66



References

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Review

For citations:


Romanova M.I., Vaniev E.V., Churkin D.O., Abramchenko A.V., Gayda A.I., Lovacheva O.V., Samoylova A.G. Management of Adverse Events during Treatment of Tuberculosis in the Patient with Systemic Lupus Erythematosus. Tuberculosis and Lung Diseases. 2023;101(4):80-86. (In Russ.) https://doi.org/10.58838/2075-1230-2023-101-4-80-86

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)