Immediate and Postponed Results of Short-Course Chemotherapy Regimens Containing Bedaquiline in Tuberculosis Patients with Multiple Drug Resistance
https://doi.org/10.58838/2075-1230-2023-101-4-72-79
Abstract
The objective: to evaluate immediate and postponed efficacy of MDR TB patients' treatment with short-course chemotherapy regimens.
Subjects and Methods. Efficacy and safety of treatment with short-course chemotherapy were evaluated in 42 MDR TB patients.
Results. 36 (85,7%) patients completed treatment successfully, 1 (2,4%) patient died of non-tuberculosis, and 5 (11,9%) patients defaulted from treatment. There were no such outcomes as treatment failure and died of TB. Over the 4-year follow-up period after successful treatment completion, tuberculosis relapse was detected in 1 (1,8%) patient. No adverse events that required chemotherapy discontinuation were reported, amendment of chemotherapy regimen was required in 7 (16,7%) patients.
About the Authors
P. N. Golubchikov
Yaya District Hospital
Russian Federation
Russian Federation
Petr N. Golubchikov - District Phthisiologist.
32, Aviatsionnaya St., Yaya, Kemerovo Region, 652100
Phone: +7 (964) 093-21-54
T. I. Petrenko
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation
Russian Federation
Tatiana I. Petrenko - Doctor of Medical Sciences, Chief Researcher.
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-83-58
D. Yu. Schegertsov
Tomsk Phthisiopulmonology Medical Center
Russian Federation
Russian Federation
Dmitry Yu. Schegertsov - Head of Multiple Drug Resistant Tuberculosis Department no. 2.
17, R. Luxemburg St., Tomsk, 634009
Phone: +7 (3822) 91-13-55
E. P. Stepanova
Tomsk Phthisiopulmonology Medical Center
Russian Federation
Russian Federation
Ekaterina P. Stepanova - Head of Respiratory Tuberculosis Department.
17, R. Luxemburg St., Tomsk, 634009
Phone: +7 (3822) 91-14-75
I. I. Pravdina
Tomsk Phthisiopulmonology Medical Center
Russian Federation
Russian Federation
Irina I. Pravdina - Head of Day Center.
17, R. Luxemburg St., Tomsk, 634009
Phone: +7 (3822) 901771
I. Yu. Pershina
Tomsk Phthisiopulmonology Medical Center
Russian Federation
Russian Federation
Irina Yu. Pershina - Head of Hospital at Home.
17, R. Luxemburg St., Tomsk, 634009
Phone: +7 (3822) 70-17-71
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Review
For citations:
Golubchikov P.N., Petrenko T.I., Schegertsov D.Yu., Stepanova E.P., Pravdina I.I., Pershina I.Yu. Immediate and Postponed Results of Short-Course Chemotherapy Regimens Containing Bedaquiline in Tuberculosis Patients with Multiple Drug Resistance. Tuberculosis and Lung Diseases. 2023;101(4):72-79. (In Russ.) https://doi.org/10.58838/2075-1230-2023-101-4-72-79
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