Pulmonary Tuberculosis in a Child with Noonan Syndrome (A Clinical Case)
https://doi.org/10.58838/2075-1230-2025-103-2-88-92
Abstract
The article presents a clinical observation of a rare case of concurrent tuberculosis and congenital disease (Noonan syndrome) in a 14-year-old child. Noonan syndrome manifested by multiple stigmas of dysembryogenesis, heart defect, delayed physical and sexual development, cryptorchidism, and keel-shaped chest deformity. At the age of 6 years, the boy was exposed to two relatives suffering from tuberculosis with a positive result of the sputum test, he received no preventive treatment. He was diagnosed with tuberculosis at the age of 14 years when infiltrative changes in the lung were detected by X-ray. During diagnosis, it is worth highlighting that the result of Interferon-Gamma Release Assay (IGRA – T-SPOT TB) was positive, while the result of the TRA test was negative. No bacterial excretion was detected during the entire period of the disease, tuberculosis had no specific course and was successfully cured.
About the Authors
L. N. Midaeva
St. Petersburg State Pediatric Medical University, Russian Ministry of Russia Health
Russian Federation
Russian Federation
Leyla N. Midaeva - Post Graduate Student of Phthisiology Department
2 Litovskaya St., St. Petersburg, 194100
Phone: +7 (812) 321-33-36
M. E. Lozovskaya
St. Petersburg State Pediatric Medical University, Russian Ministry of Russia Health
Russian Federation
Russian Federation
Marina E. Lozovskaya - Doctor of Medical Sciences, Professor, Head of Phthisiology Department
2 Litovskaya St., St. Petersburg, 194100
Phone: +7 (812) 321-33-36
Yu. A. Yarovaya
St. Petersburg State Pediatric Medical University, Russian Ministry of Russia Health
Russian Federation
Russian Federation
Yulia A. Yarovaya - Candidate of Medical Sciences, Associate Professor of Phthisiology Department
2 Litovskaya St., St. Petersburg, 194100
Phone: +7 (812) 321-33-36
E. B. Vasilieva
St. Petersburg State Pediatric Medical University, Russian Ministry of Russia Health
Russian Federation
Russian Federation
Elena B. Vasilieva - Candidate of Medical Sciences, Associate Professor of Phthisiology Department
2 Litovskaya St., St. Petersburg, 194100
Phone: +7 (812) 321-33-36
L. V. Klochkova
St. Petersburg State Pediatric Medical University, Russian Ministry of Russia Health
Russian Federation
Russian Federation
Lyudmila V. Klochkova - Candidate of Medical Sciences, Associate Professor of Phthisiology Department
2 Litovskaya St., St. Petersburg, 194100
Phone: +7 (812) 321-33-36
N. D. Shibakova
Children Infectious Hospital no. 3
Russian Federation
Russian Federation
Natalia D. Shibakova - Head of Phthisiology Department
77/17 VO, Bolshoy Ave., St. Petersburg, 199106
Phone: +7 (812) 321-33-36
References
1. Aksenova V.A., Levi D.T., Aleksandrova N.V., Kudlay D.A., Baryshnikova L.A., Klevno N.I. Tuberculosis in children: contemporary methods of prevention and early detection. Doktor.Ru, 2017, vol. 144, no. 15, pp. 9-15. (In Russ.)
2. Bukaeva A.A., Kotlukova N.P., Zaklyazminskaya E.V. Noonan syndrome as result of mutation p. s257l of gene RAF1: clinical case and review. Russian Journal of Cardiology, 2016, no. 10, pp. 93-97. (In Russ.)
3. Kudlay D.A., Starshinova A.A., Dovgalyuk I.F. Tuberculous recombinant allergen: 10-year experience of using this test in children and adolescents in the Russian Federation (data of meta analysis). Pediatria n.a. G.N. Speransky, 2020, vol. 99, no. 3, pp. 121-129. (In Russ.)
4. Lozovskaya M.E., Yarovaya Yu.A., Vasilieva E.B., Khamchieva L.N., Mosina A.V., Gavrilov P.V. Changes in the lungs of a child with Gaucher disease: differential diagnosis with disseminated tuberculosis. Tuberculosis and Lung Diseases, 2020, vol. 98, no. 10, pp. 47-51. (In Russ.)
5. Tozliyan E.V. Difficulties in the differential diagnosis of Noonan syndrome. Praktika Pediatra, 2015, no. 1, pp. 45-53. (In Russ.)
6. Faassen M.V. RAS-pathies: Noonan syndrome and other related diseases. Literature review. Problems of Endocrinology, 2014, vol. 60, no. 6, pp. 45-52. (In Russ.)
7. Bhambhani V., Muenke M. Noonan syndrome. Am. Fam. Physician, 2014, vol. 89, no. 1, pp. 37-43.
Review
For citations:
Midaeva L.N., Lozovskaya M.E., Yarovaya Yu.A., Vasilieva E.B., Klochkova L.V., Shibakova N.D. Pulmonary Tuberculosis in a Child with Noonan Syndrome (A Clinical Case). Tuberculosis and Lung Diseases. 2025;103(2):88-92. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-2-88-92
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