Results of Preventive Chemotherapy of Tuberculosis in HIV-Infected Women of Reproductive Age in Nizhny Novgorod Region
https://doi.org/10.58838/2075-1230-2026-104-1-20-25
Abstract
The objective: to analyze results of preventive chemotherapy of tuberculosis in HIV-infected women of the reproductive age.
Subjects and Methods. The results of tuberculosis preventive chemotherapy were retrospectively analyzed in 675 HIV-positive women aged 18-44 years for 2015-2019 (continuous sampling). The comparison group consisted of 6018 HIV-infected female patients of the same age who received no preventive chemotherapy of tuberculosis during the analyzed period.
Results. The average age of women receiving preventive chemotherapy of tuberculosis (PC TB+ Group) made 32.9±0.2 years. Isoniazid was well tolerated with the drug discontinued due to adverse events only in 11/675 (1.6±2.9%) women. Only 316/675 (46.8±3.6%) women completed the full 6-month course of preventive chemotherapy; the rest defaulted within the first 3 months. From PC TB+ Group, 19/675 (0.7±2.7%) patients developed tuberculosis within the next 5 years. Among 348 women who defaulted within the first 3 months, 17 (4.9±1.5%) developed tuberculosis.
Conclusion. The obtained results prove the feasibility of preventive chemotherapy of tuberculosis in HIV-positive women of the reproductive age, as it reduces the incidence of tuberculosis in the following 5 years (19/675 (0.7±2.7% versus 447/6018 (7.4±2.7%) women who developed TB, OR = 2.77, CI (1.73-4.42)). Even though 46.8±3.6% of women defaulted from preventive chemotherapy within the first 3 months.
About the Authors
G. F. Rusanovskaya
Privolzhsky Research Medical University, Russian Ministry of Health; Lobachevsky State University of Nizhny Novgorod
Russian Federation
Russian Federation
Galina F. Rusanovskaya, Candidate of Medical Sciences,
Associate Professor of I.S. Nikolaev Phthisiology Department, Associate Professor of Department of Multidisciplinary Clinical Training, Clinical Medicine Institute
10/1 Minina and Pozharskogo Sq., Nizhny Novgorod,
603005;
Phone: +7 (831)422-12-50
I. A. Kasyanova
Privolzhsky Research Medical University, Russian Ministry of Health; Nizhny Novgorod Center for AIDS and Infectious Diseases Prevention and Control
Russian Federation
Russian Federation
Irina A. Kasyanova, Assistant of Epidemiology, Microbiology and Evidence-Based Medicine Department, Head of Statistics and Reporting Department
10/1 Minina and Pozharskogo Sq., Nizhny Novgorod,
603005;
Phone: +7 (831)422-12-50
A. S. Shprykov
Privolzhsky Research Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Aleksandr S. Shprykov, Doctor of Medical Sciences, Professor
10/1 Minina and Pozharskogo Sq., Nizhny Novgorod,
603005;
Phone: +7 (831)422-12-50
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Review
For citations:
Rusanovskaya G.F., Kasyanova I.A., Shprykov A.S. Results of Preventive Chemotherapy of Tuberculosis in HIV-Infected Women of Reproductive Age in Nizhny Novgorod Region. Tuberculosis and Lung Diseases. 2026;104(1):20-25. (In Russ.) https://doi.org/10.58838/2075-1230-2026-104-1-20-25
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