Frequency of adverse reactions during chemotherapy for genital tuberculosis in patients with infertility and high treatment adherence

Abstract

The investigation enrolled 60 infertile patients diagnosed with genital tuberculosis who had completed a basic cycle of etiotropic specific antituberculosis treatment. 53.3% of the women developed adverse reactions (ARs) to anti-TB drugs. In the majority (78.1%) of the patients, chemotherapy for genital tuberculosis was complicated by one type of ARs. In the patients with genital tuberculosis and infertility, the most common AR to anti-TB agents was drug-induced hepatitis that was noted in 62.5% of the women. Digestive comorbidity and high adherence to antituberculosis therapy favored the development of ARs in most patients. ARs to anti-TB drugs did not affect the efficiency of treatment for genital tuberculosis in infertile women; however, they contributed to longer treatment in hospital.