Treatment results of patients with multiple and extensive drug resistance registered in 2012 in the Russian Federation and in the world
Abstract
The chemotherapy results have been analyzed in tuberculosis patients suffering from multiple drug resistance registered for treatment in the Russian Federation in 2011-2012 compared with the treatment outcomes of MDR patients registered for treatment in the world, BRICS and countries of the former Soviet Union in 2011. Treatment outcomes of XDR TB patients have been analyzed for the first time. Chemotherapy efficiency in MDR TB patients in the Russian Federation in the cohort of 2011 made 37.1%, and in the cohort of 2012 made 39.1%, which significantly lower than in the world in general (47.5%), in BRICS and countries of the former Soviet Union; this low treatment efficiency is mostly due to treatment failures (18.3%) and those died (19.1%). The treatment efficiency of XDR TB patients registered for treatment in the Russian Federation in 2012 made 26.2% versus 22.0% in the cohort of 2011. Considering the significant financial costs spent on the treatment, the chemotherapy efficiency of M/XDR TB patients in the Russian Federation is too low to improve the epidemic situation and some additional measures are to be taken for its improvement.
About the Authors
S. A. Sterlikov
M. I. Sechenov First Moscow State Medical University
Russian Federation
Moscow
Russian Federation
Moscow
V. V. Testov
Central Tuberculosis Research Institute
Russian Federation
Moscow
Russian Federation
Moscow
I. A. Vasilieva
Central Tuberculosis Research Institute
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Avilov K.K. Matematicheskoe modelirovanie zabolevaemosti tuberkulezom organov dykhaniya na territorii Rossii i otsenka effektivnosti protivotuberkuleznykh meropriyatiy. Diss. kand. phyz.-mat. nauk. [Mathematic simulation of respiratory tuberculosis incidence in Russia and evaluation of tuberculosis control measures efficiency. Cand. Diss.]. Moscow, 2007, 154 p.
2. Vasilieva I.A., Testov V.V., Kasaeva T.Ch. Rezul’taty lecheniya patsientov, zaregistrirovannykh v 2011 g. dlya lecheniya po IV rezhimu khimioterapii. Otraslevye i ekonomicheskye pokazateli protivotuberkuleznoy raboty v 2012-2013 gg. Analitichesky obzor osnovnykh pokazateley i statisticheskiye materialy. [Treatment outcomes of patients registered for treatment in 2011 as regimen VI. In: Economic rates for TB control in 2012-2013. Analysis of main rates and statistic materials]. Edited by S.A. Sterlikov, Moscow, RIO TsNIIOIZ Publ., 2014, pp. 18-20. (In Russ.)
3. Obukhova O.V., Sterlikov S.А., Nechaeva O.B. Finansirovanie meropriyatiy po bor’be s tuberkulezom i sostoyanie osnovnykh fondov protivotuberkuleznykh meditsinskikh organizatsiy. Otraslevye i ekonomicheskye pokazateli protivotuberkuleznoy raboty v 2012-2013 gg. Analitichesky obzor osnovnykh pokazateley i statisticheskiye materialy. [Funding of tuberculosis control activities and state of main assers of TB medical units. Economic rates for TB control in 2012-2013. Analysis of main rates and statistic materials]. Ed. by S.A. Sterlikov, Moscow, RIO TsNIIOIZ Publ., 2014, pp. 20-24. (In Russ.)
4. Sterlikov S.A. Problem of drug resistant tuberculosis control in the Russian Federation. Zdorovye Naseleniya i Sreda Obitaniya, no. 6, pp. 21-23. (In Russ.)
5. Einis V.L. Lechenie bol’nogo legyochnym tuberkulyozom. [Treatment of a tuberculosis patient]. Moscow, Medgiz Publ., 1949. 150 p.
6. Global database: treatment outcomes [Epub. Available at:] https://extranet.who.int/tme/generateCSV.asp?ds = outcomes
7. Global strategy and targets for tuberculosis prevention, care and control after 2015. Document EB134/12 [Epub.]. Available at: http://apps.who.int/gb/ebwha/pdf_files/EB134/B134_12-en.pdf
8. Global tuberculosis report 2014. WHO/HTM/TB/2014.08. 154 p.
9. Styblo K., Bumgarner J.R. Tuberculosis can be controlled with existing technologies: evidence. The Hague: Tuberculosis Surveillance Research Unit Progress Report; 1991. pp. 60-72.
10. The Global Plan to Stop TB 2006-2015 [Epub.]. Geneva, 2006. WHO/HTM/STB/2006.35 Available at: http://www.stoptb.org/assets/documents/global/plan/GP_P1_S1.pdf
11. Toman’s tuberculosis case detection, treatment and monitoring: questions and answers / ed. by T. Frieden. 2nd ed., Geneva, 2004, 386 p.
Review
For citations:
Sterlikov S.A., Testov V.V., Vasilieva I.A. Treatment results of patients with multiple and extensive drug resistance registered in 2012 in the Russian Federation and in the world. Tuberculosis and Lung Diseases. 2016;94(1):22-27. (In Russ.)
Views:
759
Email this article 