OPPORTUNITIES OF VARIOUS IMMUNOLOGICAL TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN HIV PATIENTS
https://doi.org/10.21292/2075-1230-2016-94-8-14-22
Abstract
Co-infection of tuberculosis and HIV-infection continues to be the current crucial issue not only due to the persistent growth of HIV-infection but also due difficulties in diagnostics of tuberculosis. Often X-ray changes in the lungs are atypical, clinical signs are manifested only in case of the severe and disseminated disease. At present the IGRA-tests are widely used worldwide while in Russia TRA tests are used. The trial provided the data on the use and comparative efficiency of the above immunological tests against Mantoux test with 2 TU when examining 239 persons from 2014 to 2015. The comparativeness of diagnostic sensitivity of all immunological tests had been proved. The specificity of IGRA-tests and TRA tests is twice higher compared to Mantoux test with 2 TU. Also it was proved that when diagnosing tuberculosis in HIV patients the skin tests (Mantoux test with 2 TU and TRA test) had low diagnostic informativeness compared to IGRA tests, among which ELISPOT was the most sensitive.
About the Authors
A. A. Starshinova
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of Phthisiopulmonology Department,
2-4, ligovsky Ave., St. Petersburg, 191036
A. M. Panteleev
Municipal Tuberculosis Hospital no. 2;
Pavlov First saint Petersburg State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor of Social infections Department,
93, Morisa torеza Ave., St. Petersburg, 194214
V. V. Manina
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Post-Graduate Student,
2-4, ligovsky Ave., St. Petersburg, 191036
E. V. Istomina
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Pulmonologist,
2-4, ligovsky Ave., St. Petersburg, 191036D. N. Afonin
St. Petersburg Research Institute of Phthisiopulmonology;
Medical Physics Department, Peter the Great st. Petersburg Polytechnic University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of Scientific technical information Department,
2-4, ligovsky Ave., St. Petersburg, 191036
V. Yu. Zhuravlev
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of laboratory Diagnostics Department,
2-4, ligovsky Ave., St. Petersburg, 191036
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Review
For citations:
Starshinova A.A., Panteleev A.M., Manina V.V., Istomina E.V., Afonin D.N., Zhuravlev V.Yu. OPPORTUNITIES OF VARIOUS IMMUNOLOGICAL TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN HIV PATIENTS. Tuberculosis and Lung Diseases. 2016;94(8):14-22. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-8-14-22
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