INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION
https://doi.org/10.21292/2075-1230-2016-94-9-24-29
Abstract
Goal of the study: to develop individual approaches to the choice of chemotherapy regimens for respiratory tuberculosis in children exposed to multiple drug resistant tuberculous infection.
Materials and methods. Totally 39 children (3-12 years old) with tuberculosis of chest lymph nodes or pulmonary tuberculosis. Patients were divided into 3 groups: Group 1 (9 persons) with minimal changes – 3 drugs (ZPASPtо), Group 2 (15 persons) with limited lesions – 4 drugs (ZPtоPASE), Group 3 (15 persons) with disseminated lesions – 5 drugs (ZPASPtоAmFq). Duration of chemotherapy: Group 1 – 9.4 ± 0.7 months; Group 2 – 9.0 ± 1.1 months (administration of 4 drugs during the whole treatment course) and 10.5 ± 0.9 months, (transfer after the intensive phase (3.1 ± 0.7 months) to 3 drugs), Group 3 – 13.4 ± 0.7 months. (Transfer after the intensive phase (4.0 ± 0.4 months) to 4 drugs).
Results. Chemotherapy course was assessed assuccessful in all groups. Individual approaches to the choice of chemotherapy regimens oftuberculosis in children exposed to multiple drug resistant tuberculous infection should consider not only the data on drug susceptibility of the infection source but also the dissemination of tuberculous lesions in the child.
About the Authors
M. F. Gubkina
Central Tuberculosis Research Institute;
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Doctor of Medical sciences, leading Researcher of the Department for Tuberculosis Control in Children and adolescents within Therapy Faculty,
2, Yauzskaya alleya, Moscow, 107564
Yu. Yu. Khokhlova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Junior Children Department,
2, Yauzskaya alleya, Moscow, 107564
N. V. Yukhimenko
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical sciences, leading Researcher of Children and adolescents Department,
2, Yauzskaya alleya, Moscow, 107564
I. Yu. Petrakova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Medical sciences, Head of Junior Children Department,
2, Yauzskaya alleya, Moscow, 107564
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Review
For citations:
Gubkina M.F., Khokhlova Yu.Yu., Yukhimenko N.V., Petrakova I.Yu. INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION. Tuberculosis and Lung Diseases. 2016;94(9):24-29. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-9-24-29
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