DIAGNOSTIC VALUE OF GENE XPERT MTB-RIF IN TUBERCULOSIS CONTROL PRACTICE
https://doi.org/10.21292/2075-1230-2016-94-10-37-39
Abstract
The article presents the data on the use of Gene Хpert MBT-RIF testing in 122 patients. In 69 (56.6%) patients the diagnosis of tuberculosis was confirmed, and some other non-tuberculous pulmonary diseases were verified in 53 (43.4%) patients. Efficiency of tuberculous causative agent detection by Gene Xpert was compared to routine bacteriological methods. The sensitivity of this method made 63.8%, specificity made 98.1%, prognostic value of the positive result - 97.8%, prognostic value of negative result - 67.5%. Factors associated with positive results of this method are presented.
About the Authors
Zh. A. Laushkina
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Medical Sciences, Senior Researcher,
81a, Okhotskaya St., Novosibirsk, 630040
V. A. Krasnov
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Honored Doctor of Russia, Director,
81a, Okhotskaya St., Novosibirsk, 630040
A. G. Cherednichenko
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Head of Bacteriological Laboratory,
81a, Okhotskaya St., Novosibirsk, 630040
References
1. Greco S., Girardi E., Navarra A., Saltini C. Current evidence on diagnostic accuracy of commercially based nucleic acid amplification tests for the diagnosis of pulmonary tuberculosis. Thorax, 2006, no. 61, pp. 783-790.
2. Ling D.I., Flores L.L., Riley L.W., Pai M. Commercial nucleic-acid amplification tests for diagnosis of pulmonary tuberculosis in respiratory specimens: meta-analysis and meta-regression. PLoS One, 2008, no. 3, pp. e1536.
3. Park J.S., Kang Y.A., Kwon S.Y. et al. Nested PCR in lung tissue for diagnosis of pulmonary tuberculosis. Eur. Respir. J., 2010, no. 35, pp. 851-857.
4. Theron G., Pooran A., Peter J. et al. Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting? Eur. Respir. J., 2012, vol. 40, no. 1, pp. 161-168.
5. Weyer K., Mirzayev F., Migliori G. et al. Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF. Eur. Respir. J., 2013, no. 42, pp. 252-271.
6. WHO, Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children: policy update. Geneva; 2013.
Review
For citations:
Laushkina Zh.A., Krasnov V.A., Cherednichenko A.G. DIAGNOSTIC VALUE OF GENE XPERT MTB-RIF IN TUBERCULOSIS CONTROL PRACTICE. Tuberculosis and Lung Diseases. 2016;94(10):37-39. (In Russ.) https://doi.org/10.21292/2075-1230-2016-94-10-37-39
Views:
2052
Email this article 