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SPECIFIC FEATURES OF ANTI-TUBERCULOSIS CHEMOTHERAPY TOLERANCE IN THE LIGHT OF PSYCHOLOGICAL STATUS OF PATIENTS

https://doi.org/10.21292/2075-1230-2017-95-4-15-19

Abstract

Specific features of psychological state were studied in 295 pulmonary tuberculosis patients with satisfactory tolerance to anti-tuberculosis medications and 75 patients poorly tolerating the treatment.

Before the treatment start the patients who later demonstrated adverse reactions to treatment were diagnosed with more intense neurotic and hypochondriac personal features, destructive reactions and higher level of emotional tension and frustration – all the above promote dysregulation of the host adaptation. The research demonstrated the need to consider psychological aspects when studying the tolerance to anti-tuberculosis chemotherapy. 

About the Authors

N. V. Zolotova
Central Tuberculosis Research Institute
Russian Federation

Candidate of Physiological Sciences, Senior Researcher of the Group Studying Psychological Problems Related to Tuberculosis, Children and Adolescents Department,

2, Yauzskaya Alleya, Moscow, 107564



G. V. Baranova
Central Tuberculosis Research Institute
Russian Federation

Candidate of Physiological Sciences, Senior Researcher of the Group Studying Psychological Problems Related to Tuberculosis, Children and Adolescents Department,

2, Yauzskaya Alleya, Moscow, 107564



V. V. Streltsov
Central Tuberculosis Research Institute
Russian Federation

Candidate of Physiological Sciences, Senior Researcher of the Group Studying Psychological Problems Related to Tuberculosis, Children and Adolescents Department,

2, Yauzskaya Alleya, Moscow, 107564



N. Yu. Kharitonova
Central Tuberculosis Research Institute
Russian Federation

Clinical Psychological of the 1st Therapy Department,

2, Yauzskaya Alleya, Moscow, 107564



A. A. Аkhtyamova
Central Tuberculosis Research Institute
Russian Federation

Candidate of Physiological Sciences, Senior Researcher of the Group Studying Psychological Problems Related to Tuberculosis, Children and Adolescents Department,

 2, Yauzskaya Alleya, Moscow, 107564


T. R. Bagdasaryan
ФГБНУ «Центральный НИИ туберкулеза»
Russian Federation

Head of the 1st Therapy Department,

2, Yauzskaya Alleya, Moscow, 107564



References

1. Vinogradova L.V. Specific emotional state in pulmonary tuberculosis patients with various courses of the disease. Tuberculosis and Lung Diseases, 2011, no. 4, pp. 85-86. (In Russ.)

2. Garkavi L.Kh., Kvakina E.B., Kuzmenko T.S. Аntistressornye reaktsii i aktivatsionnaya terapiya. [Anti-stress reactions and activation therapy]. Moscow, 1998. 565 p.

3. Danilov D.S. Compliance with treatment: definition, ways of formation and optimization. Nevrologiya, Neyropsikhiatriya, Psikhosomatika, 2014, no. 2, pp. 4-12. (In Russ.)

4. Ivanova D.А., Borisov S.E., Ryzhov А.M., Ivanushkina T.N. Frequency and risk of severe adverse reactions development in the treatment of new tuberculosis patients. Tuberculosis and Lung Diseases, 2012, no. 12, pp. 15-22. (In Russ.)

5. Ivanova D.А., Borisov S.E., Ryzhov А.M., Ivanushkina T.N. Frequency, typical features and risk factors of drug-induced liver lesions when treating new tuberculosis patients. Tuberculosis and Lung Diseases, 2013, no. 11, pp. 25-31. (In Russ.)

6. Kiseleva N.M., Kuzmenko L.G., Nkane Nkoza M.M. Stress and lymphocytes. Pediatriya, 2012, no. 1, pp. 137-143. (In Russ.)

7. Kiseleva Yu.Yu., Vasilieva I.А., Kazenny B.Ya. et al. Actual issues of tuberculosis patients treatment under current conditions and factors providing influence on chemotherapy efficiency. Tuberculosis and Lung Diseases, 2012, no. 9, pp. 16-21. (In Russ.)

8. Meerson F.Z. Аdaptatsiya, stress i profilaktika. [Adaptation, stress and prevention]. Moscow, Nauka Publ., 1981, 278 p.

9. Pankratova L.E. Psychological state of new pulmonary tuberculosis patients and its impact on the tolerance to anti-tuberculosis drugs. Probl. Tub., 1988, no. 3, pp. 74-77. (In Russ.)

10. Stepanova N.А., Streltsova E.N., Galimzyanov Kh.M., Kantemirova B.I. Adverse reactions to first line anti-tuberculosis drugs. Tuberculosis and Lung Diseases, 2016, no. 5, pp. 42-45. (In Russ.)

11. Tashpulatova F.K., Mukhamediev I.K., Аbdurazakova Z.K., Dolgusheva Yu.V. Frequency and character of adverse reactions in the patients suffering from drug resistant pulmonary tuberculosis. Meditsina: vyzovy segodnyashnego dnya: materialy III Mezhdunar. nauch. konf. [Medicine: Current Challenges. Materials of the IIIrd International Research Conference]. Moscow, Buki-Vedi Publ., 2016, pp. 50-53. (In Russ.)

12. Feschenko Yu.I., Cherenko S.А., Maltsev V.I. et al. Evaluation of importance of adverse reactions to TB drugs during treatment of tuberculosis. Ukr. Med. Journal, 3 (65), V/VI 2008.

13. Tseylikman O.B. Provospalitelnye i antivospalitelnye gepatotropnye effekty khronicheskogo stressa i monooksigenaznaya sistema pecheni. Avtoref. diss. dokt. med. nauk. [Pro-inflammatory and anti-inflammatory hepatotrophic effects of chronic stress and liver monooxygenase system. Doct. Diss.]. Omsk, 2005, 48 p.

14. Shkurupy V.A. Ultrastruktura kletok pecheni pri stresse. [Fine structure of liver cells under stress]. Novosibirsk, Nauka Publ., 1989, 143 p.


Review

For citations:


Zolotova N.V., Baranova G.V., Streltsov V.V., Kharitonova N.Yu., Аkhtyamova A.A., Bagdasaryan T.R. SPECIFIC FEATURES OF ANTI-TUBERCULOSIS CHEMOTHERAPY TOLERANCE IN THE LIGHT OF PSYCHOLOGICAL STATUS OF PATIENTS. Tuberculosis and Lung Diseases. 2017;95(4):15-19. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-4-15-19

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)