ANALYSIS OF THE PATIENTS REFERRED FOR TREATMENT TO NOVOSIBIRSK TUBERCULOSIS RESEARCH INSTITUTE FROM THE AREAS SUPERVISED BY THIS INSTITUTE. CHANGES IN CHEMOTHERAPY EFFICIENCY AFTER INTRODUCTION OF THE UPDATED TREATMENT REGIMENS AND MICROBIOLOGICAL DIAGNOSTICS
https://doi.org/10.21292/2075-1230-2017-95-8-52-57
Abstract
In 2015 the implementation of Edicts no. 951 by the Russian Ministry of Health On Guidelines on Improvement of Respiratory Tuberculosis Treatment and Diagnostics was started.
Goal of the study: to analyze the characteristics of tuberculosis patients referred to treatment to Novosibirsk Tuberculosis Research Institute (NTRI) in 2014-2016 from the areas supervised by the Institute; to evaluate the clinical assessment of comprehensive chemotherapy efficiency after the introduction of the updated treatment regimens and express methods of microbiological diagnostics.
Materials and methods: a prospective cohort study was conducted using the data of 481 patients referred for treatment to NTRI from the areas supervised by it, i.e. Siberian and Far Eastern Federal Districts.
Results. Among the patients referred for treatment to NTRI in 2014-2016, new tuberculosis cases with multiple/extensive drug resistance (64.3-80.5%) and pulmonary destructions (67.9-82.7%) were very frequent. Among the patients already receiving treatment and referred to NTRI, the part of those with progressing course of the disease reduced from 35.0% in 2014 down to 9.7% in 2016 as well as the part of those with concurrent bronchial tuberculosis reduced from 41.3% in 2014 down to 27.9% in 2016.
After introduction of the provisions of the Edict to NTRI, treatment efficiency of new patients improved assessed as per the cessation of bacillary excretion (by sputum smear microscopy: in 2016 – 91.7%, in 2014 – 75%; by culture: in 2016 – 90.9%, in 2014 г. – 77.3%).
About the Authors
E. P. Myshkova
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Acting Head of Pulmonary Tuberculosis Department no. 2,
81a, Okhotskaya St., Novosibirsk, 630040
E. M. Zhukova
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences, Senior Researcher,
81a, Okhotskaya St., Novosibirsk, 630040
T. A. Reykhrud
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Head of Pulmonary Tuberculosis Department no. 2,
81a, Okhotskaya St., Novosibirsk, 630040
References
1. Vasilieva I.А., Testov V.V., Kasaeva T.Ch. Rezultaty lecheniya patsientov, zaregistrirovannykh v 2011 g. dlya lecheniya po IV rezhimu khimioterapii. [Treatment outcomes for patients notified for treatment in 2011 as per regimen IV]. In: Otraslevye i ekonomicheskye pokazateli protivotuberkuleznoy raboty v 2012-2013 gg. Analitichesky obzor osnovnykh pokazateley i statisticheskiye materialy. [Economic rates for TB control in 2012-2013. Analysis of main rates and statistic materials]. Edited by S.A. Sterlikov, Moscow, RIO TsNIIOIZ Publ., 2014, pp. 18-20. (In Russ.)
2. Zhukova E.M., Krasnov V.А., Khazanov V.А. The efficiency of adding a regulator of the energy metabolism into the comprehensive treatment of pulmonary tuberculosis patients. Bulleten Sibirskogo Otdeleniya RAMN, 2009, no. 5, pp. 46-52. (In Russ.)
3. Krasnov V.А., Ursov I.G. Bactericidal therapy of tuberculosis patients. Probl. Tub., 2004, no. 3, pp. 21-26. (In Russ.)
4. Kurunov Yu.N., Kononenko V.G., Panteleeva А.G., Pirogov V.I., Lisichenko G.M., Krasnov V.А. Eksperimentalnoe obosnovanie intermittiruyuschey vnutrivennoy khimioterapii tuberkuleza. Uspekhi intermittiruyuschey khimioterapii otkrytykh form tuberkuleza. [Experimental validation of intermittent intravenous chemotherapy of tuberculosis. Successful use of intermittent chemotherapy in the infectious forms of tuberculosis]. Novosibirsk, 1982, pp. 57-64.
5. Petrenko T.I., Filimonov P.N., Krasnov V.А., Reykhrud T.А. Results of intravenous intermittent chemotherapy in pulmonary tuberculosis patients with concurrent chronic viral hepatites. Bulleten' VSNTS SO RAMN, 2011, no. 2, pp. 87-90. (In Russ.)
6. Edict no. 951 by RF MoH as of 29.12.2014 On Approval of Guidelines for Improvement of Respiratory Tuberculosis Diagnostics and Treatment. (In Russ.) 41 p.
Review
For citations:
Myshkova E.P., Zhukova E.M., Reykhrud T.A. ANALYSIS OF THE PATIENTS REFERRED FOR TREATMENT TO NOVOSIBIRSK TUBERCULOSIS RESEARCH INSTITUTE FROM THE AREAS SUPERVISED BY THIS INSTITUTE. CHANGES IN CHEMOTHERAPY EFFICIENCY AFTER INTRODUCTION OF THE UPDATED TREATMENT REGIMENS AND MICROBIOLOGICAL DIAGNOSTICS. Tuberculosis and Lung Diseases. 2017;95(8):52-57. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-8-52-57
Views:
1214
Email this article 