EFFICIENCY OF VALVE BRONCHIAL BLOCK AS A PART OF THE COMPREHENSIVE TREATMENT OF DESTRUCTIVE PULMONARY TUBERCULOSIS WITH CONCURRENT HIV INFECTION
https://doi.org/10.21292/2075-1230-2017-95-8-67-72
Abstract
Goal of the study: to enhance the efficiency of the comprehensive treatment of destructive pulmonary tuberculosis in HIV patients using bronchial valve block.
Materials and methods. A study was conducted enrolling two groups of tuberculosis patients with destructive drug resistant pulmonary forms and concurrent HIV infection having comparable clinical and laboratory characteristics. Treatment of the patients in the main group (n = 68) included valve bronchial block. Patients from the comparison group (n = 57) received the same treatment but without valve bronchial block.
Results of the study. Adding valve bronchial block to the treatment of tuberculosis is a positive factor confidently promoting sputum conversion (OR = 4.13; 95% CI 3.50-4.75) and healing of cavities (OR = 3.89; 95% CI 3.30-4.48). When using valve bronchial block the healing of cavities made 55.9%, while in the comparison group it made only 24.6%; (p = 0.0004, χ2 ). Sputum conversion was achieved in 75.0%, and in the comparison group, this rate was 42.1% (p = 0.0002, χ2 ). The above rates varied respectively the degree of immunosuppression in the patients.
About the Authors
Ya. K. Petrova
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Phthisiologist, Post-Graduate Student,
81a, Okhotskaya St., Novosibirsk, 630040
D. V. Krasnov
Novosibirsk Tuberculosis Research Institute;
Novosibirsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of Pulmonary Surgery Department,
81a, Okhotskaya St., Novosibirsk, 630040
S. V. Sklyuev
Novosibirsk Tuberculosis Research Institute;
Novosibirsk State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Endoscopist,
81a, Okhotskaya St., Novosibirsk, 630040
T. V. Zyryanova
Novosibirsk State Medical University
Russian Federation
Novosibirsk State Medical University, Associate Professor of Phthisiopulmonology Department
Russian Federation
Novosibirsk State Medical University, Associate Professor of Phthisiopulmonology Department
References
1. VICH-infektsiya: inform. byul. no. 40. [HIV infection: Inform. Bull. no. 35]. Federal Scientific Methodical Center for AIDS Prevention and Control Publ., Moscow, 2015, pp. 56. [Epub. Available at: http://hivrussia.org/stat/bulletin.shtml#40.]
2. Dobkina M.N. et al. Organization of treatment in patients with TB/HIV co-infection in Tomsk Region. Tuberculosis and Lung Diseases, 2014, no. 1, pp. 78. (In Russ.)
3. Zimina V.N., Vasilieva I.А., Batyrov F.А., Samoylova А.G. Chemotherapy efficiency in tuberculosis patients with HIV co-infection. Tuberculosis and Lung Diseases, 2013, no. 3, pp. 15-21. (In Russ.)
4. Levin А.V., Tseymakh E.А., Samuylenkov А.M., Zimonin P.E., Omelchenko S.А., Chukanov I.V. Valve bronchial block in the treatment of disseminated drug resistant pulmonary tuberculosis patients. Probl. Tub., 2007. no. 4, pp. 13-16. (In Russ.)
5. Lovacheva O.V., Elkin А.V., Zimonin P.E., Krasnov D.V., Krasnov V.А., Levin А.V., Sklyuev S.V., Skornyakov S.N., Stepanov D.V., Tseymakh E.А., Shumskaya I.Yu. Federalnye klinicheskie rekomendatsii po ispolzovaniyu metoda klapannoy bronkhoblokatsii v lechenii tuberkuleza legkikh i ego oslozhneniy. [Federal clinical recommendations on using valve bronchial block in the treatment of pulmonary tuberculosis and its complications]. Moscow, 2015, 24 p.
6. Manicheva O.А., Lasunskaya E.B., Zhuravlev V.Yu. et al. Drug susceptibility of Mycobacterium tuberculosis compared to their viability, cytotoxicity, genotype and course of the disease in respiratory tuberculosis patients. Probl. Tub., 2008, no. 12, pp. 18-22. (In Russ.)
7. Mordyk A.V. et al. Tuberculosis with concurrent HIV infection: causes of treatment failures. Omskiy Nauchny Vestnik, 2015, no. 2 (144), pp. 23-26. (In Russ.)
8. Panteleev A.M. Patogenez, klinika, diagnostika i lechenie tuberkuleza u bolnykh VICH- infektsiey. Diss. dokt. med. nauk. [Pathogenesis, symptoms, diagnostics and treatment of tuberculosis in HIV patients. Doct. Diss.]. 2012, pp. 45.
9. Federalnye klinicheskie rekomendatsii po diagnostike i lecheniyu tuberkuleza u bolnykh VICH-infektsiey. [Federal clinical recommendations on diagnostics and treatment of tuberculous in HIV patients]. Moscow, 2014, pp. 28.
10. Khazova E.Yu., Ivanova N.А. Difficulties in diagnostics and treatment of the patients with HIV-associated tuberculosis. Bulleten Meditsinskikh Internet Konferentsiy, 2014.
Review
For citations:
Petrova Ya.K., Krasnov D.V., Sklyuev S.V., Zyryanova T.V. EFFICIENCY OF VALVE BRONCHIAL BLOCK AS A PART OF THE COMPREHENSIVE TREATMENT OF DESTRUCTIVE PULMONARY TUBERCULOSIS WITH CONCURRENT HIV INFECTION. Tuberculosis and Lung Diseases. 2017;95(8):67-72. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-8-67-72
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