CHARACTERISTICS AND EFFICIENCY OF TREATMENT IN TUBERCULOSIS PATIENTS DEPENDING ON THE ХPERT MTB/RIF RESULTS
https://doi.org/10.21292/2075-1230-2017-95-9-30-33
Abstract
The goal of the study: to evaluate treatment efficiency of pulmonary tuberculosis patients resistant to rifampicin when treatment was prescribed based on the results of Xpert MBT/RIF. The social and clinical structure was retrospectively analyzed in 165 new pulmonary tuberculosis patients, treated in the in-patient unit of Municipal Clinical Phthisiopulmonary Hospital (Kishineu Mun.). Patients were divided into 2 groups: the main group included 85 patients, in whom the result of Xpert MTB/RIF was positive and resistant to rifampicin, the control group included 80 patients in whom the result of Xpert MTB/RIF was positive and susceptible to rifampicin; certain parameters of the groups were compared. Only 65/80 (81.2%) patients of the control group had a complete treatment course, and 61/85 (71.8%) of the main group, the rest of the patients was lost to follow-up. Evaluation of the outcomes of the complete treatment course showed no confident difference between drug susceptible tuberculosis patients and those resistant to rifampicin, provided that treatment was prescribed with the consideration of Xpert MBT/RIF data.
About the Author
A. M. MАLIK
State University of Medicine and Pharmaceutics "Nicolae Testemitanu"
Moldova, Republic of
Moldova, Republic of
Assistant of Phthisiopulmonology Department Phone/Fax: (373 22) 24-34-08; (373 22) 24-23-44
165, Stefan cel Mare si Sfant, Bd., MD-2004, Chişinau, Republic of Moldova
References
1. Seregina V.А., Budritskiy А.M. Current opportunities of pulmonary tuberculosis diagnostics. Vestn. Vitebskogo. Gos. Med. Universiteta, 2016, vol. 15, no. 4, pp. 7-17. (In Russ.)
2. Bates M., O'Grady J., Maeurer M. Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study . Lancet Infect. Dis., 2013, vol. 13, no. 1, pp. 36-42.
3. Boehme C.C., Nabeta P., Hillemann D. Rapid molecular detection of tuberculosis and rifampin resistance. N. Engl. J. Med., 2010, vol. 363, no. 11, pp. 1005-1015.
4. Ustian A., Crudu V., Malic A., Niguleanu A., Lesnic E. Aspectele clinico- radiologice, microbiologice şi eficacitatea tratamentului la pacienţi cu tuberculoza pulmonară diagnosticaţi prin Xpert MTB/RIF. . Buletinul Academiei de Știință a Moldovei. Științe Medicale, 2016, vol. 1, no. 50, pp. 59-62.
5. WHO/ Global tuberculosis report 2016.
Review
For citations:
MАLIK A.M. CHARACTERISTICS AND EFFICIENCY OF TREATMENT IN TUBERCULOSIS PATIENTS DEPENDING ON THE ХPERT MTB/RIF RESULTS. Tuberculosis and Lung Diseases. 2017;95(9):30-33. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-9-30-33
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