Immunodiagnostics of tuberculosis: 10-year experience of using immunological tests in Russia
https://doi.org/10.21292/2075-1230-2019-97-5-58-65
Abstract
The introduction of a new generation of immunological tests based on in vitro or in vivo reactions using specific ЕSAT-6 and CFP-10 peptides allowed changing the understanding of the diagnosis of latent tuberculosis infection, as well as improving the diagnosis of tuberculosis in pediatric and adult practice. The article presents the analysis of the Russian studies conducted over the past ten years aimed to investigate the informativeness of a skin test with tuberculosis recombinant allergen. High diagnostic significance of the skin test, comparable to the internationally recognized IGRA-tests has been proved. Today, the test with TRA in the form of locally manufactured Diaskintest has been introduced inRussianot only to the practice of TB units, but also in the practice of pediatricians, pulmonologists and infectious disease specialists.
About the Authors
A. A. Starshinova
St. Petersburg University
Russian Federation
Russian Federation
Anna A. Starshinova - St. Petersburg University, St. Petersburg, Russia Doctor of Medical Sciences, Leading Researcher.
7-9, Universitetskaya Nab., St. Petersburg, 199034
I. F. Dovgalyuk
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Irina F. Dovgalyuk - Doctor of Medical Sciences, Professor, Leading Researcher,
Head of Phthisiopediatrics Direction.
2-4, Ligovskiy Ave., St. Petersburg, 191036, Phone: +7 (812) 297-22-63
P. K. Yablonskiy
St. Petersburg University;
St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Petr K. Yablonskiy - Doctor of Medical Sciences, Professor, Director.
2-4, Ligovskiy Ave., St. Petersburg, 191036, Phone: +7 (812) 775-75-50
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For citations:
Starshinova A.A., Dovgalyuk I.F., Yablonskiy P.K. Immunodiagnostics of tuberculosis: 10-year experience of using immunological tests in Russia. Tuberculosis and Lung Diseases. 2019;97(5):58-65. (In Russ.) https://doi.org/10.21292/2075-1230-2019-97-5-58-65
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