Comparative Assessment of Liver Function During the Intensive Phase of Treatment of Respiratory Tuberculosis Patients Treated with First Line and Reserve Drugs
https://doi.org/10.21292/2075-1230-2021-99-7-41-47
Abstract
The objective: to compare liver function of respiratory tuberculosis patients during the intensive phase of treatment with first line drugs (chemotherapy regimen 1) and reserve drugs (chemotherapy regimens 4 and 5).
Subjects and Methods: Data of 144 respiratory tuberculosis patients were analyzed, those patients were divided into 2 groups. Group 1 included 67 patients receiving chemotherapy regimen 1 and Group 2 included 77 patients treated with chemotherapy regimens 4 or 5. During the first 3 months of treatment, the frequency and severity of changes in the liver function were assessed.
Conclusion: in patients with chronic viral hepatitis, parenchymal liver damage is more frequent and it improves slower. Transaminase levels returned to normal levels more frequently and rapidly with chemotherapy regimen 1, whereas with chemotherapy regimens 4 and 5, reduction of alanine aminotransferase level was observed only from the 2nd month of treatment.
About the Authors
E. V. Vаniev
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Eduard V. Vaniev – Candidate of Medical Sciences, Head of Therapy Department no. 2.
4, Dostoevsky St., Moscow, 127473
N. V. Kuzminа
Surgut State University
Russian Federation
Russian Federation
Natalya V. Kuzmina – Professor of Department for Multiple Discipline Clinical Training.
1, Lenina Ave., Surgut, KhMAO-Yugra, 628412
I. А. Vаsilyevа
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Irina A. Vasilyeva – Doctor of Medical Sciences, Professor, Director.
4, Dostoevsky St., Moscow, 127473
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Review
For citations:
Vаniev E.V., Kuzminа N.V., Vаsilyevа I.А. Comparative Assessment of Liver Function During the Intensive Phase of Treatment of Respiratory Tuberculosis Patients Treated with First Line and Reserve Drugs. Tuberculosis and Lung Diseases. 2021;99(7):41-47. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-7-41-47
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