Experience of Using Bedaquiline in a Young Child with Drug Resistant Tuberculosis and Concurrent Primary Immunodeficiency
https://doi.org/10.21292/2075-1230-2021-99-8-47-53
Abstract
The article describes a clinical case of the treatment of a young child with a complicated course of tuberculosis with multiple localizations and concurrent primary immunodeficiency. The new anti-tuberculosis drug of bedaquiline was successfully used in the treatment regimen. The child received bedaquiline for 6 months without any adverse events, after 2 months no acid-fast mycobacteria were detected, there were pronounced positive radiological changes which remained until the end of treatment. This clinical case provides evidence that bedaquiline can be used safely and effectively in MDR TB chemotherapy regimens in children under 5 years of age.
About the Authors
T. I. Danilova
Leningrad Regional TB Dispensary
Russian Federation
Russian Federation
Danilova Tatiana I., Candidate of Medical Sciences, Deputy Chief Physician for Medical Activities
Phone: 412-01-63
20, Lenina St., Slantsy, Slantsevsky Region, Leningrad Region, 188560
Fax: 412-00-04.
N. А. Barmina
Leningrad Regional TB Dispensary
Russian Federation
Russian Federation
Barmina Natalya A., Candidate o f Medical Sciences, Head of Consultative Pediatric Department for Children and Adolescents
Phone: 412-01-45
20, Lenina St., Slantsy, Slantsevsky Region, Leningrad Region, 188560
Fax: 412-00-04.
E. S. Borisova
Vyborg Regional Tuberculosis Hospital
Russian Federation
Russian Federation
Borisova Evgeniya S., Deputy Head Doctor for Medical Activities
2, Sbornaya St., Vyborg, Leningrad Region, 188800
Phone: +7(81378) 2-78-38
L. А. Maksimova
Vyborg Regional Tuberculosis Hospital
Russian Federation
Russian Federation
Maksimova Liudmila A., Head of Pediatric Tuberculosis Department
2, Sbornaya St., Vyborg, Leningrad Region, 188800
Phone: +7(81378) 2-78-38
Yu. V. Kornev
Leningrad Regional TB Dispensary
Russian Federation
Russian Federation
Korneev Yury V., Chief Doctor, Doctor of Superior Merritt of Russia
Phone: 412-01-45
20, Lenina St., Slantsy, Slantsevsky Region, Leningrad Region, 188560
Fax: 412-00-04
References
1. Акsепоvа V. А., Baryshnikova L. А., Klevno N. I., Kudlay D. A. Screening of children and adolescents for tuberculosis infection in Russia - past, present, future. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 9, pp. 59-67. (In Russ.)
2. Аksenova V. A., Levi D. T., Аleksandrova N. V., Kudlay D. A., Baryshnikova L. А., Klevno N. I. Tuberculosis in children: contemporary methods of prevention and early detection. Doktor.Ru, 2017, no. 15 (144), pp. 9-15. (In Russ.)
3. Barmina N. A., Baryshnikova L. A.. Characteristics of manifestations of tuberculosis infection in children and adolescents with the identified index case using Perm Kray as an example. Voprosy Prakticheskoy Pediatrii, 2019, vol. 14, no. 2, pp. 21-28. (In Russ.)
4. Golubchikov P. N., Kruk Е. А., Mishustin S. P., Petrenko T. I., Kudlay D. A. Experience of treating extensive drug resistant tuberculosis patients including continuous use of bedaquiline, in Tomsk Region: immediate and postponed results. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 8, pp. 38-45. (In Russ.)
5. Kaminskiy G. D., Kudlay D. А., Panova А. Е., Parolina L. E., Peregudova А. Т., Pshenichnaya N. Yu., Samoylova А G., Testov V. V., Tinkova V. V. Taktika vracha pri vyyavlenii, diagnostike i profilaktike sochetannoy infektsii VICH i tuberkulez: prakticheskoe rukovodstvo. [Tactics of the physician in the detection, diagnosis and prevention of TB/HIV coinfection. Practical guide]. I.A. Vasilyeva, eds., Moscow, 2020, 152 p.
6. Kudlay D. A.., Starshinova А. А., Dovgalyuk I. F. Tuberculous recombinant allergen: 10-year experience of using this test in children and adolescents in the Russian Federation (data of meta analysis). Pediatriya im. G.N. Speranskogo, 2020, vol. 99, no. 3, pp. 121-129. (In Russ.)
7. Edict no. 125n by the Russian Ministry of Health as of 21.03.2014 On Approval the National Vaccination Calendar and Vaccination Calendar Based on Epidemic Indications (Revision as of 09.12.2020). (Registration no. 32115 by Russian Ministry of Justice as of 25.04.2014). (In Russ.)
8. Stavitskaya N. V., Felker I. G., Zhukova E. M., Tlif А.I., Doktorova N. P., Kudlay D. A.. The multivariate analysis of the results of bedaquiline use in the therapy of MDR/XDR pulmonary tuberculosis. Tuberculosis and Lung Diseases, 2020, vol. 98, no. 7, pp. 56-62. (In Russ.)
9. Federal klinicheskie rekomendatsii VICH-infektsiya u detey. [Federal guidelines on HIV infection in children]. Moscow, 2020.
10. Federalnye klinicheskie rekomendatsii .Tuberkulez u vzroslykh. [Federal clinical guidelines on tuberculosis in adults]. Moscow, 2020.
11. Slogotskaya L. V., Bogorodskaya E., Sentchichina O., Ivanova D., Nikitina G., Litvinov V., Seltsovsky, P., Kudlay D.A., Nikolenko N., Borisov S. Effectiveness of tuberculosis detection using a skin test with allergen recombinant (CFP-10-ESAT-6) in children. Eur. Respir. J., 2015, vol. 46, no. S59, РА4524.
Review
For citations:
Danilova T.I., Barmina N.А., Borisova E.S., Maksimova L.А., Kornev Yu.V. Experience of Using Bedaquiline in a Young Child with Drug Resistant Tuberculosis and Concurrent Primary Immunodeficiency. Tuberculosis and Lung Diseases. 2021;99(8):47-53. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-8-47-53
Views:
656
Email this article 