Preview

Tuberculosis and Lung Diseases

Advanced search

Analysis of Complications of Transbronchial Lung Cryobiopsy in Patients with Disseminated Lung Diseases

https://doi.org/10.58838/2075-1230-2025-103-4-70-74

Abstract

The objective: to study the frequency and spectrum of complications after transbronchial lung cryobiopsy.
Subjects and Methods. A continuous retrospective study was conducted, which included 138 patients with pulmonary tissue dissemination syndrome. All those patients were treated in Novosibirsk Tuberculosis Research Institute from January 2023 to December 2024. To verify the diagnosis, all patients underwent transbronchial lung cryobiopsy. The authors assessed the diagnostic effectiveness of biopsy and complications that developed.
Results. Transbronchial lung cryobiopsy allowed to verify the diagnosis in 109 (78.9%) of 138 patients. Complications were registered in 125 (90.6%) patients: bleeding – in 89.1%, grade 3 bleeding – in 3.6%, and pneumothorax – in 2.2%. There were no lethal outcomes.

About the Authors

S. V. Sklyuev
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation

Sergey V. Sklyuev, Candidate of Medical Sciences, Head of Endoscopy Department

81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25



N. B. Muzaev
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation

Naran B. Muzaev, Endoscopist

81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25



E. M. Zhukova
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation

Elena M. Zhukova, Doctor of Medical Sciences, Leading Researcher

81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25



N. V. Stavitskaya
Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health
Russian Federation

Natalia V. Stavitskaya, Doctor of Medical Sciences, Director

81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25



References

1. Bekov M.T., Pashkov I.V., Latypov R.A., Oleshkevich D.O., Shigaev E.F., Smirnov K.S., Yakunin Ya.S., Gautier S.V. Transbronchial cryobiopsy in lung transplant recipients. Russian Journal of Transplantology and Artificial Organs, 2023, vol. 25, no. S, pp. 57. (In Russ.)

2. Belyaev G.S., Vasiliev I.V., Mamenko I.S., Tabanakova I.A., Novitskaya T.A., Yablonskiy P.K. Comparison of the efficacy of transbronchial cryobiopsy with transbronchial forceps biopsy in the diagnosis of diffuse parenchymal lung diseases. Meditsinsky Alyans, 2022, vol. 10, no. 2, pp. 40-49. (In Russ.) https://doi.org/10.36422/23076348-2022-10-2-40-49.

3. Chesalina Ya.O. Transbronchial cryobiopsy in differential diagnostics of peripheral lung lesions. CTRI Bulletin, 2023, no. S1, pp. 109-110. (In Russ.) https://doi.org/10.57014/2587-6678-2023-5-109-110

4. Cavazza A., Colby T.V., Dubini A., Tomassetti S., Ravaglia C., Poletti V., Mengoli M.C., Tagliavini E., Rossi G. Transbronchial cryobiopsy in the diagnosis of diffuse lung disease. Surg. Pathol. Clin., 2020, vol. 13, no. 1, pp. 197-208. https://doi.org/10.1016/j.path.2019.11.004

5. Chami H.A., Diaz-Mendoza J., Chua A., Duggal A., Jenkins A.R., Knight S.L., Patolia S., Tamae-Kakazu M., Raghu G., Wilson K.C. Transbronchial biopsy and cryobiopsy in the diagnosis of hypersensitivity pneumonitis among patients with interstitial lung disease. Ann. Am. Thorac. Soc., 2021, vol. 18, no. 1, pp. 148-161. https://doi.org/10.1513/AnnalsATS.202005-421OC

6. Folch Erik E. et al. Standardized definitions of bleeding after transbronchial lung biopsy. Chest, 2000, no. 1, pp. 393-400. https://doi.org/10.1016/j.chest.2020.01.036

7. Mikolasch T.A., Garthwaite H.S., Porter J.C. Update in diagnosis and management of interstitial lung disease. Clin. Med. (Lond.), 2016, vol. 16, suppl 6, pp. s71-s78. https://doi.org/10.7861/clinmedicine.16-6-s71

8. Raghu G., Remy-Jardin M., Myers J.L. et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am. J. Respir. Crit. Care Med., 2018, vol. 198, no. 5, pp. e44-68.

9. Ravaglia C., Bonifazi M., Wells A.U. et al. Safety and diagnostic yield of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a comparative study versus video-assisted thoracoscopic lung biopsy and a systematic review of the literature. Respiration, 2016, vol. 91, no. 3, pp. 215-227.


Review

For citations:


Sklyuev S.V., Muzaev N.B., Zhukova E.M., Stavitskaya N.V. Analysis of Complications of Transbronchial Lung Cryobiopsy in Patients with Disseminated Lung Diseases. Tuberculosis and Lung Diseases. 2025;103(4):70-74. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-4-70-74

Views: 9


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)