Analysis of Complications of Transbronchial Lung Cryobiopsy in Patients with Disseminated Lung Diseases
https://doi.org/10.58838/2075-1230-2025-103-4-70-74
Abstract
The objective: to study the frequency and spectrum of complications after transbronchial lung cryobiopsy.
Subjects and Methods. A continuous retrospective study was conducted, which included 138 patients with pulmonary tissue dissemination syndrome. All those patients were treated in Novosibirsk Tuberculosis Research Institute from January 2023 to December 2024. To verify the diagnosis, all patients underwent transbronchial lung cryobiopsy. The authors assessed the diagnostic effectiveness of biopsy and complications that developed.
Results. Transbronchial lung cryobiopsy allowed to verify the diagnosis in 109 (78.9%) of 138 patients. Complications were registered in 125 (90.6%) patients: bleeding – in 89.1%, grade 3 bleeding – in 3.6%, and pneumothorax – in 2.2%. There were no lethal outcomes.
About the Authors
S. V. SklyuevRussian Federation
Sergey V. Sklyuev, Candidate of Medical Sciences, Head of Endoscopy Department
81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25
N. B. Muzaev
Russian Federation
Naran B. Muzaev, Endoscopist
81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25
E. M. Zhukova
Russian Federation
Elena M. Zhukova, Doctor of Medical Sciences, Leading Researcher
81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25
N. V. Stavitskaya
Russian Federation
Natalia V. Stavitskaya, Doctor of Medical Sciences, Director
81A Okhotskaya St., Novosibirsk, 630040 Phone: + 7 (383) 203-78-25
References
1. Bekov M.T., Pashkov I.V., Latypov R.A., Oleshkevich D.O., Shigaev E.F., Smirnov K.S., Yakunin Ya.S., Gautier S.V. Transbronchial cryobiopsy in lung transplant recipients. Russian Journal of Transplantology and Artificial Organs, 2023, vol. 25, no. S, pp. 57. (In Russ.)
2. Belyaev G.S., Vasiliev I.V., Mamenko I.S., Tabanakova I.A., Novitskaya T.A., Yablonskiy P.K. Comparison of the efficacy of transbronchial cryobiopsy with transbronchial forceps biopsy in the diagnosis of diffuse parenchymal lung diseases. Meditsinsky Alyans, 2022, vol. 10, no. 2, pp. 40-49. (In Russ.) https://doi.org/10.36422/23076348-2022-10-2-40-49.
3. Chesalina Ya.O. Transbronchial cryobiopsy in differential diagnostics of peripheral lung lesions. CTRI Bulletin, 2023, no. S1, pp. 109-110. (In Russ.) https://doi.org/10.57014/2587-6678-2023-5-109-110
4. Cavazza A., Colby T.V., Dubini A., Tomassetti S., Ravaglia C., Poletti V., Mengoli M.C., Tagliavini E., Rossi G. Transbronchial cryobiopsy in the diagnosis of diffuse lung disease. Surg. Pathol. Clin., 2020, vol. 13, no. 1, pp. 197-208. https://doi.org/10.1016/j.path.2019.11.004
5. Chami H.A., Diaz-Mendoza J., Chua A., Duggal A., Jenkins A.R., Knight S.L., Patolia S., Tamae-Kakazu M., Raghu G., Wilson K.C. Transbronchial biopsy and cryobiopsy in the diagnosis of hypersensitivity pneumonitis among patients with interstitial lung disease. Ann. Am. Thorac. Soc., 2021, vol. 18, no. 1, pp. 148-161. https://doi.org/10.1513/AnnalsATS.202005-421OC
6. Folch Erik E. et al. Standardized definitions of bleeding after transbronchial lung biopsy. Chest, 2000, no. 1, pp. 393-400. https://doi.org/10.1016/j.chest.2020.01.036
7. Mikolasch T.A., Garthwaite H.S., Porter J.C. Update in diagnosis and management of interstitial lung disease. Clin. Med. (Lond.), 2016, vol. 16, suppl 6, pp. s71-s78. https://doi.org/10.7861/clinmedicine.16-6-s71
8. Raghu G., Remy-Jardin M., Myers J.L. et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am. J. Respir. Crit. Care Med., 2018, vol. 198, no. 5, pp. e44-68.
9. Ravaglia C., Bonifazi M., Wells A.U. et al. Safety and diagnostic yield of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a comparative study versus video-assisted thoracoscopic lung biopsy and a systematic review of the literature. Respiration, 2016, vol. 91, no. 3, pp. 215-227.
Review
For citations:
Sklyuev S.V., Muzaev N.B., Zhukova E.M., Stavitskaya N.V. Analysis of Complications of Transbronchial Lung Cryobiopsy in Patients with Disseminated Lung Diseases. Tuberculosis and Lung Diseases. 2025;103(4):70-74. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-4-70-74