A Clinical Case of Successful Treatment of Generalized Tuberculosis in a Patient with Promyelocytic Leukemia
https://doi.org/10.58838/2075-1230-2025-103-4-82-91
Abstract
The article presents a clinical case describing difficulties of diagnosing tuberculosis in a patient with acute promyelocytic leukemia during therapy with retinoic acid derivatives and arsenic trioxide. Immediacy and individual approach to treatment and diagnosing tactics made it possible to effectively complete the course of treatment for acute promyelocytic leukemia and generalized tuberculosis achieving a cure of these diseases.
About the Authors
V. V. Tinkova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health;
Pirogov Russian National Research Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Valentina V. Tinkova, Candidate of Medical Sciences, Deputy Head Physician for Medical Activities, Associate Professor of Phthisiology Department
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
1 Ostrovityanova St., Moscow, 117513 Phone: +7 (495) 434-22-66
L. D. Nazarova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Lyudmila D. Nazarova, Phthisiologist of Differential Diagnostic Department
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
P. V. Senchikhin
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
Russian Federation
Russian Federation
Pavel V. Senchikhin, Candidate of Medical Sciences, Head of Department, Phthisiologist of Differential Diagnostic Department
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
N. V. Kuzmina
National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health;
Pirogov Russian National Research Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Natalya V. Kuzmina, Doctor of Medical Sciences, Chief Researcher of Department of Differential Diagnosis and Treatment of Tuberculosis and Concurrent Infections, Professor of Phthisiology Department
4 Build. 2 Dostoevsky St., Moscow, 127473 Phone: +7 (495) 631-15-15
1 Ostrovityanova St., Moscow, 117513 Phone: +7 (495) 434-22-66
M. A. Bulgakov
Pirogov Russian National Research Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Maksim A. Bulgakov, Resident
1 Ostrovityanova St., Moscow, 117513 Phone: +7 (495) 434-22-66
References
1. Vasilyeva I.A., Samoylova A.G., Zimina V.N., Lovacheva O.V., Abramchenko A.V. Chemotherapy for tuberculosis in Russia – the story continues. Tuberculosis and Lung Diseases, 2023, vol. 101, no. 2, pp. 8-12. (In Russ.) http://doi.org/10.58838/2075-1230-2023-101-2-8-12
2. Lapshina I.S., Tsybikova E.B., Kotlovskiy M.Yu. Groups at high risk of developing respiratory tuberculosis among adult population of Kaluga Oblast. Tuberculosis and Lung Diseases, 2022, vol. 100, no. 11, pp. 20-28. (In Russ.) http://doi.org/10.21292/2075-1230-2022-100-11-20-28
3. Parovchinikova E.N., Troitskaya V.V., Sokolov A.N., Klyasova G.A., Galstyan G.M., Kuzmina L.A., Domracheva E.V., Dvirnyk V.N., Savchenko V.G. Treatment of adult patients with acute promyelocytic leukemia according to the AIDA protocol. Terapevticheskiy Arkhiv, 2013, no. 7, pp. 10-17. (In Russ.)
4. Semenova A.A., Troitskaya V.V., Galtseva I.V., Parovichnikova E.N. Risk factors for a differentiation syndrome in patients with acute promyelocytic leukemia. Oncohematology, 2023, vol. 18, no. 3, pp. 50-56. (In Russ.) http://doi.org/10.17650/1818-8346-2023-18-3-50-56
5. Troitskaya V.V., Parovichnikova E.N., Semenova A.A., Fidarova Z.T., Sokolov A.N., Galstyan G.M., Spirin M.V., Gribanova E.O., Sysoeva E.P., Dvirnyk V.N., Naumova I.N., Obukhova T.N., Glinshchikova O.A., Klyasova G.A., Chabaeva Yu.A., Kulikov S.M., Savchenko V.G. Risk-adapted combined therapy with arsenic trioxide and all-trans-retinoic acid for de novo acute promyelocytic leuкaemia. Russian Journal of Hematology and Transfusiology, 2021, vol. 66, no. 2, pp. 168-191. (In Russ.) https://doi.org/10.35754/0234-5730-2021-66-2-168-191
6. Federalnye klinicheskiye rekomendatsii Promiyelotsitarnyy leykoz. [Federal guidelines for promyelocytic leuкaemia]. Moscow, 2022.
7. Abdullah A.S., Adel A.M., Hussein R.M., Abdullah M.A., Yousaf A., Mudawi D., Mohamed S.F., Nashwan A.J., Soliman D., Ibrahim F., Yassin M.A. Hypercalcemia and acute pancreatitis in a male patient with acute promyelocytic leukemia and pulmonary tuberculosis. Acta Biomed., 2018, vol. 89, no. 3-S, pp. 23-27. http://doi.org/10.23750/abm.v89i3-S.7216
8. Boldig K., Kiamos A., Matthews-New T., Omman R., Quan W. Acute promyelocytic leukemia treatment masking hepatic tuberculosis: a management dilemma. Journal of Hematology (North America), 2023, no. 12. Available: https://thejh.org/index.php/jh/article/view/1109/731 Accessed August 17, 2024
9. Chen C.Y., Sheng W.H., Cheng A. et al. Clinical characteristics and outcomes of Mycobacterium tuberculosis disease in adult patients with hematological malignancies. BMC Infect. Dis., 2011, no. 11, pp. 324. https://doi.org/10.1186/1471-2334-11-324
10. Dropulic L.K., Dropulic L.K., Lederman H.M. Overview of infections in the immunocompromised host. Microbiol. Spectr., 2016, no. 4, pp. 4. http://doi.org/10.1128/microbiolspec
11. Jain A., Jain A., Prakash G., Singh C., Lad D., Khadwal A., Suri V., Malhotra P., Kumari S., Varma N., Varma S. Analysis of clinical profile and outcome of tuberculosis in patients with acute leukemia. Indian J. Hematol. Blood Transfus., 2018, vol. 34, no. 3, pp. 430-442. http://doi.org/10.1007/s12288-017-0875-z
12. Liu C.J., Hong Y.C., Liu C.J., Hong Y.C., Teng C.J., Hung M.H., Hu Y.W., Ku F.C., Chen Y.T., Chien S.H., Yeh C.M., Chen T.J., Chiou T.J., Gau J.P., Tzeng C.H. Risk and impact of tuberculosis in patients with chronic myeloid leukemia: a nationwide population-based study in Taiwan. Int. J. Cancer, 2015, vol. 136, no. 8, pp. 1881-1887. http://doi.org/10.1002/ijc.29201
13. Lo-Coco F. Retinoic acid and arsenic trioxide for APL. N. Engl. J. Med., 2013, vol. 369, no. 2, pp. 111-121.
14. Machuca I., Vidal E., Machuca I., Vidal E., de la Torre-Cisneros J., Rivero-Román A. Tuberculosis in immunosuppressed patients. Enferm. Infecc. Microbiol. Clin. (Engl. Ed.), 2018, vol. 36, no. 6, pp. 366-374. http://doi.org/10.1016/j.eimc.2017.10.009
15. Mishra P., Kumar R., Mishra P., Kumar R., Mahapatra M., Sharma S., Dixit A., Chaterjee T., Choudhry D.R., Saxena R., Choudhry V.P. Tuberculosis in acute leukemia: a clinico-hematological profile. Hematology, 2006, vol. 11, no. 5, pp. 335-340. http://doi.org/10245330600915818
16. Omri H., Taha El Omri H., Taha R., Ibrahim W., Kassem N., Szabados L., El Sabah H., Abid F.B., Gamiel A., Al Khinji A., Szmeigielski W., Hasan S. and Al Hijji I. Diagnostic delay and associated clinical features of tuberculosis among adult patients with acute myeloid leukemia in Doha, Qatar. Journal of Tuberculosis Research, 2018, no. 6, pp. 49-62.
17. Palta A., Dhiman P., Cruz S.D. ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature. Korean J. Hematol., 2012, vol. 47, no. 3, pp. 229-232. http://doi.org/10.5045/kjh.2012.47.3.229
18. Platzbecker U., Avvisati G., Cicconi L., Thiede C., Paoloni F., Vignetti M., Ferrara F. et al. Improved outcomes with retinoic acid and arsenic trioxide compared with retinoic acid and chemotherapy in non-high-risk acute promyelocytic leukemia: final results of the randomized Italian-German APL0406 Trial. J. Clin Oncol., 2017, vol. 35, no. 6, pp. 605-612. http://doi.org/10.1200/JCO.2016.67.1982
19. Qbal P., Soliman A., De Sanctis V., Yassin M.A. Association of tuberculosis in patients with chronic myeloid leukemia: a treatment proposal based on literature review. Expert. Rev. Hematol., 2021, vol. 14, no. 2, pp. 211-217. http://doi.org/10.1080/17474086.2021.1875818
20. Realegeno S., Adeyiga O., Winston D.J., Beaird O.E., Garner O.B., Yang S. Utilization of whole genome sequencing for resolution of discrepant Mycobacterium tuberculosis drug susceptibility results: a case report. IDCases, 2021, no. 26, pp. e01308. http://doi.org/10.1016/j.idcr.2021.e01308
21. Villa V.D., Moreno E.M., Zapata N. Clinical features and diagnostic delay of tuberculosis (tb) in patients with acute myeloid leukemia. (AML). Blood, 2019, vol. 134, suppl. 1, pp. 5114. https://doi.org/10.1182/blood-2019-128158.
22. Yang F.Y., Shao L., Su J., Zhang Z.M. Carrimycin in the treatment of acute promyelocytic leukemia combined with pulmonary tuberculosis: A case report. World J. Clin. Cases, 2024, vol. 12, no. 3, pp. 623-629. http://doi.org/10.12998/wjcc.v12.i3.623
Review
For citations:
Tinkova V.V., Nazarova L.D., Senchikhin P.V., Kuzmina N.V., Bulgakov M.A. A Clinical Case of Successful Treatment of Generalized Tuberculosis in a Patient with Promyelocytic Leukemia. Tuberculosis and Lung Diseases. 2025;103(4):82-91. (In Russ.) https://doi.org/10.58838/2075-1230-2025-103-4-82-91
Views:
8
Email this article 