Experience in treating drug-resistant tuberculosis in patients with HIV infection
Abstract
The paper describes the experience in treating 30 patients with drug- and multidrug-resistant tuberculosis and HIV infection (median CD4+ lymphocyte count was 629 cells/µl; 8 patients received antiretroviral therapy). Only 11 (36.7%) patients effectively completed a basic treatment cycle; failing therapy was stated in 3 (10%) patients and it was associated with the amplification of drug resistance (n = 2) and progressive tuberculosis with generalization in a patient with low baseline CD4+ lymphocyte counts (101 cells/µl) (n = 1); early treatment termination was seen in 16 (53.3%) cases. Fourteen (46.7%) patients were noted to have adverse events of treatment with second-line (reserve) drugs, among which allergic reactions were prevalent (n = 7 (23.3%)).
About the Authors
A. I. Gordon
ГКУЗ КО «Новокузнецкий клинический противотуберкулезный диспансер»
Russian Federation
Russian Federation
I. B. Viktorova
ГБОУ ДПО «Новокузнецкий государственный институт усовершенствования врачей» МЗ и СР РФ
Russian Federation
Russian Federation
S. A. Dolgikh
ГБОУ ДПО «Новокузнецкий государственный институт усовершенствования врачей» МЗ и СР РФ
Russian Federation
Russian Federation
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Review
For citations:
Gordon A.I., Viktorova I.B., Dolgikh S.A. Experience in treating drug-resistant tuberculosis in patients with HIV infection. Tuberculosis and Lung Diseases. 2014;(12):66-68. (In Russ.)
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