Preview

Tuberculosis and Lung Diseases

Advanced search

ACTIVITY OF TUBERCULOSIS WHEN CALCIFICATION IS DETECTED IN THE CHEST LYMPH NODES AND LUNGS OF CHILDREN

https://doi.org/10.21292/2075-1230-2017-95-1-11-17

Abstract

Introduction of new examination techniques to tuberculosis control in children resulted in the increase of Group IIIA of the dispensary follow-up.

Goal: to define criteria of tuberculosis disease activity when calcification is detected in the chest lymph nodes of children. Follow-up included children in the age from 1,5 months to 17 years old examined in TB dispensaries of Yekaterinburg and Tyumen. 1A Subgroup (n = 145) of children demonstrated further increase and/or induration of calcification and in 27 children calcification did not change (1B Subgroup). In Subgroup 2A1  – 184 patients had changes in the X-ray manifestations, 31 persons demonstrated calcification in chest lymph nodes (Subgroup 2A2 ), 13 persons demonstrated no changes in X-ray manifestations which was considered as metatuberculous (fibrous) changes (2B Group). Two criteria witnessing of the absence of active tuberculosis disease were identified: infection with tuberculosis more than 4 years ago and stable level of α2-fraction in the protein profile. These indicators can serve as true criteria when no clinical signs of intoxication are observed and calcification is detected by X-ray, while the child has not been exposed to tuberculosis. 

About the Authors

A. V. Mezentseva
Ural Phthisiopulmonology Research Institute
Russian Federation

Postgraduate Student,

50, XXII Parts'ezda St., Yekaterinburg, 620039



T. E. Tyulkova
Ural Phthisiopulmonology Research Institute
Russian Federation

Doctor of Medical Sciences, Leading Researcher,

50, XXII Parts'ezda St., Yekaterinburg, 620039



Yu. P. Chugaev
Ural Phthisiopulmonology Research Institute; Ural State Medical University
Russian Federation

Doctor of Medical Sciences, Professor of Phthisiopulmonology Department with Training in Thoracic Surgery,

3, Repina St., Yekaterinburg, 620028



N. G. Kamaeva
Ural Phthisiopulmonology Research Institute; Ural State Medical University
Russian Federation

Candidate of Medical Sciences, Associate Professor, Professor of Phthisiopulmonology Department with Training in Thoracic Surgery,

3, Repina St., Yekaterinburg, 620028



I. A. Dolmatova
Regionl TB Dispensary
Russian Federation

Regional TB Dispensary, Doctor,

45, Slavyanskaya St., Yekaterinburg, 620010



References

1. Аbdullaev R.G., Kaminskaya G., Komissarova O.G. Changes in hemostasis system – components of system inflammatory response syndrome in pulmonary tuberculosis. Vrach, 2012, no. 2, pp. 24. (In Russ.)

2. Aksenova V.A. Tuberkulez u detei i podrostkov. Uchebnoye posobiye. [Tuberculosis in children and adolescents. Manual]. Moscow, GEOTAR-Media Publ., 2007, 272 p.

3. Butylchenko O.V. Clinical and immunological criteria of tuberculous infection in children and adolescents. Vestn. Zdorovye i Obrazovaniye v XXI v., 2010, no. 11. (In Russ.)

4. Gubkina M.F. Detection techniques and clinical X-ray characteristics of abacillary tuberculosis in children of the older age. Probl. Tub., 2002, no. 10, pp. 16-19. (In Russ.)

5. Dolgov V.V., Shevchenko O.P. Laboratornaya diagnostika narusheniy obmena belkov. Posobie dlya vrachey, vtoroe izdanie, pererabotannoe. [Laboratory diagnostics of protein exchange disorders. Doctors' manual, second revised edition]. Moscow, 2002, 67 p.

6. Doroshenkova А.E., Аnorina E.E., Stavitskaya N.V., Tkhakushinova N.Kh. Informativeness of immunological rates as indicators of latent tuberculous infection in children. Kuban. Nauch. Med. Vestn., 2009, no. 9, pp. 44-47. (In Russ.)

7. Zemskova Z.S., Dorozhkova I.R. Sktryto protekayuschaya tuberkuleznaya infektsia. [Latent tuberculous infection]. Moscow, Moscow, 1984, 224 p.

8. Zorkaltseva E.Yu. Haemogram and specific immunity rates in children suffering from tuberculosis. Bulleten' VSNTS SO RAMN, 2005, no. 1. (In Russ.)

9. Immunologiya i allergologiya (tsvetnoy atlas): uchebnoe posobie dlya studentov meditsinskikh vuzov. [Immunology and allergology (color atlas): Manual for medical students]. Ed. by А.А. Vorobiev, А.S. Bykov, А.V. Karaulov. Moscow, Prakticheskaya Meditsina Publ., 2006, 288 p.

10. Immunologiya, Moscow, Izdtelsky Dom MAGISTR PRESS Publ., 2013, 448 p.

11. Koretskaya N.M., Zagorulko O.V., Logunova N.А., Narkevich А.N. The value of Mantoux test with 2 TU PPD-L and diaskintest in the formation of the risk group of tuberculosis relapse in children with spontaneous cure of the disease. Pediatriya, Journal im. G.N. Speransky 2016, vol. 95, no. 2, pp. 72-77. (In Russ.)

12. Mayansky A.N. Tuberculosis (microbiological and immune-pathogenic aspects). Immunologiya, 2001, no. 2, pp. 53. (In Russ.)

13. Perelman M.I., Bogadelnokova I.V. Ftiziatriya: uchebnik. [Phthisiatry: Manual]. 2nd Edition, reviewed and supplemented, Moscow, GEOTAR-Media Publ., 2013, 453 p.

14. Stasko E.Yu., Khasanshin G.S. Analysis of using the skin test with tuberculous recombinant allergen as a screening technique for children above 7 years old in Penza Region in 2015. Tuberculosis and Lung Diseases, 2016, no. 3, pp. 52-56. (In Russ.)

15. Tyulkova T.E., Chugaev Yu.P., Kashuba E.А. Immunologicheskie osobennosti tuberkuleznoy infektsii na raznykh etapakh ee razvitiya. [Immunological specific features of tuberculous infection at the various stages of its development]. Tyumen, OOO Siti-Press Publ., 2008, 60 p.

16. Federal'nye klinicheskie rekomendatsii po diagnostike i lecheniyu latentnoy tuberkuleznoy infektsii u detey. [Federal clinical recommendations on diagnostics and treatment of latent tuberculous infection in children]. Moscow, ROOI Zdorovye Cheloveka Publ., 2015, 36 p.

17. Freydlin I.S., Totolyan А.А. Kletki immunnoy sistemy. [Cells of immune system]. St. Petersburg, Nauka Publ., 2001, 390 p.

18. Chistovich A.N. Patologicheskaya anatomiya i patogenez tuberkuleza. [Pathologic anatomy and pathogenesis of tuberculosis]. Leningrad, 1973, 175 p.

19. Shevchenko O.P., Dolgov V.V., Olefirenko G.А. Elektroforez v klinicheskoy laboratorii. I Belki syvorotki krovi. [Electrophoresis in clinical laboratory. I Proteins of blood serum]. Reafarm Publ., 2006, 112 p.

20. Shilova M.V. Tuberkulez v Rossii v 2012-2013 gg. [Tuberculosis in Russia in 2012-2013]. Moscow, 2014, 244 p.


Review

For citations:


Mezentseva A.V., Tyulkova T.E., Chugaev Yu.P., Kamaeva N.G., Dolmatova I.A. ACTIVITY OF TUBERCULOSIS WHEN CALCIFICATION IS DETECTED IN THE CHEST LYMPH NODES AND LUNGS OF CHILDREN. Tuberculosis and Lung Diseases. 2017;95(1):11-17. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-1-11-17

Views: 9150


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)