REVIEWS
ORIGINAL ARTICLES
Goal of the study: to study the efficiency of using MIRU-VNTR molecular genetic technique for molecular epidemiological studies among pulmonary tuberculosis patients.
Materials and methods: 20 patients with pulmonary tuberculosis relapses, 12 pulmonary tuberculosis patients with hetero-resistant results of drug susceptibility testing, 7 patients who developed tuberculosis during staying in a medical social unit, one adult and one child exposed to tuberculosis in their families with doubtful correlation between their diseases. The genetic pattern of M. tuberculosis strains for MIRU-VNTR 9-10 loci have been compared.
Results. 55% of tuberculosis relapses are related to infection with a new M. tuberculosis strain, the remaining cases belong to re-activation of the endogenous strain of M. tuberculosis. In case of hetero-resistant results of DST the mixed infection with two strains of M. tuberculosis was found only in 1 (8.3%) out of 12 patients, in the remaining cases M. tuberculosis belonged to the one genotype but with different resistance patterns. Contact tracing of tuberculosis break-out (7 patients) in the closed medical social unit proved the presence of several sources of the infection. Contract tracing of the family exposure proved the actual infection transmission in the family and the source of the infection was identified.
Goal of the study: to investigate the effect of low-intense laser radiation of blood on the level myeloperoxidase in those suffering from community-acquired pneumonia.
Materials and methods. 78 patients were enrolled into the study, 52 of them received the intravenous laser radiation of blood (VLOK) as per VLOK-405 technique during 7 days. The level of myeloperoxidase was tested with the help of reagents kit for blood enzyme multiplied immunoassay before and after the treatment.
Results. The analysis of the study results detected the confident improvement of myeloperoxidase rates in the group of patients receiving additional VLOK treatment. Conclusions. Using VLOK as a part of integral therapy of those suffering from community-acquired pneumonia promotes the normalization of myeloperoxidase rates.
In order to evaluate the efficiency of treatment in day hospital for pulmonary tuberculosis patients the data for 10 years have been analyzed.
Materials and methods: epidemiological rates in Orel Region for the last 10 years have been analyzed. Day hospital has been described as a treatment format substituting the in-patient treatment. Basing of the data of 734 patients registered for treatment in day hospital for 10 years the treatment efficiency has been analyzed.
Results. The tendency towards the increase in the number of TB patients receiving treatment in day hospital (from 9.7 to 14.9%), treatment efficiency in day hospital was high: the average rate made 92.0% (the same rate for Orel Region made – 80.2%, p < 0.001) with the low default rate, on the average it made – 1.2% (for Orel Region it made – 2.4%; p = 0.35).
The analysis of the other hospital substituting treatment forms detected the decrease in the number of patients receiving treatment in TB treatment rooms and feldscher stations (from 13.0% in 2004 to 3.8% in 2013) which is due to the difficulties in the provision of directly observed treatment in these units. The comprehensive use of the hospital substituting forms with the provision of the daily observation of TB drugs in-take assures high treatment efficiency rates, including in socially marginalized patients which provides the positive impact on the epidemic situation in the region.
CLINICAL OBSERVATIONS
ISSN 2542-1506 (Online)